seamus wrote: » Code freezes are only for old-school companies who plan on shutting down over Xmas. With enough cash incentive there's no reason a dedicated dev team can't work on it all the way through.
Scuid Mhór wrote: » 1. That's a misnomer -- the vaccines have been designed to last as long as they can. Most epidemiologists and virologists seem to be more convicted in the vaccines providing longer protection than natural antibodies arising from prior infection.
There's no way we can say anything definitively right now hence I would assume those who have been infected will still be required to get vaccinated in an ideal world.
schmoo2k wrote: » 1 - I may be wrong but the non mRNA vaccines are based on infecting folks with a "dead" virus to prime the immune system? Your immune system gets primed exactly the same way with the "live" virus (but obviously more dangerous). Also the antibody protection will be shorter lived than the T-Cell immunity, which they are still studying. Misnomer is a bit harsh.
Hmmzis wrote: » Not quite correct. The 'dead' virus vaccines are called inactivated whole virus vaccines. They use the whole virion deactivated in formaline and/or beta-propiolactone, that hopefully messes up the proteins only so much as to make it inert but still similar enough to the wild type to be valid as a template for your immune system to learn from. These vaccines do not infect your cells, they physically cannot do that, that's the whole point of inactivation. In order for your immune system to react to this 'dead' virus an adjuvant gets added (alum, ASO3, etc.). It's effectively a protein based vaccine using whole virus particles. These vaccines cannot induce killer cell responses (CD8+), they induce T helper cells though and hopefully the type 1 ones. Viral vectors, mRNA and live attenuated vaccines do 'infect' your cells. Viral vectors (mostly) and mRNA just do not replicate in them, while live attenuated do replicate to some extent. This induces both T helper cells and killer cells. All approaches induce antibody production and hopefully germinal centers as well to properly mature the B cells so that they can become long lived plasma cells giving you a constant background of antibodies. The wild type virus infects your cells proper, replicates a LOT and does a real mess with the inner workings of your cells in the process, inhibiting lots of interferon signaling pathways, suppressing MHC-I etc. This whole messing around with the innate cellular signaling is what's causing the disease and the observed suppressed germinal center activity.
ShineOn7 wrote: » What time is the official announcement by the "government" regarding the rollout? All I'm seeing is a soft drop on the Irish Times site with some of the presumed details so far Is there a Presser about it today?
schmoo2k wrote: » Does that mean for the asymptomatic folks the "live" virus should trigger the same immune response as the inactivated one?
is_that_so wrote: » Can't see it mentioned on the thread but Moderna on the cusp of approval in US.https://www.bbc.com/news/world-us-canada-55320467
tobefrank321 wrote: » I think they got approved. One difference to the Pfizer vaccine is the gap between doses is 4 weeks rather than 3 weeks, and after 6 weeks of first dose you have a strong immune response. Looks like the Germans have brought huge pressure on the EMA to approve Pfizer for emergency use.
tom1ie wrote: » with the above example: you are vaccinated. you catch covid at the gig covid has no effect as you are immune from the vaccine but you carry the virus you return to work in a hospital where you are dealing with people who have low immune systems and cant take the vaccine. whats the plan for this?
stephenjmcd wrote: » He's already been saying in the last few days he expects the country fully open by mid summer
tom1ie wrote: » Anyone else see this as a potential issue?
Micky 32 wrote: » It won’t be as big of an issue than if we were put in permanent lockdown and restrictions that you’re promoting to keep indefinately. The government’s aim is to get back to normal and hopefully by mid summer and rightly so.
El Sueño wrote: » I'd imagine those (hopefully rare) scenarios are something people are going to have to accept.[/quote I wonder how rare it would actually be though?
Van.Bosch wrote: » Let’s say there was never any Covid. You go to the gig, get a bad flu, go to the hospital and give it to a patient. It’s unfortunate but Covid won’t be the first disease that can be dangerous.
tom1ie wrote: » Indeed except for covid is a hell of a lot worse than flu.
schmoo2k wrote: » Same thing as if you caught it at the shops I would imagine?
tom1ie wrote: » Yeah agreed so.......what’s the plan?
ACitizenErased wrote: » Which vaccine are you referring to? Moderna, Pfizer and AZ have been shown to significantly reduce asymptomatic infection. Your scenario is quite unlikely.
tom1ie wrote: » Any of the vaccines. Ok well this is news to me and anyone I’ve asked so far. I thought they didn’t know that you couldn’t spread it once you take the vaccine? My scenario is not unlikely. What if you have a family member with a low immune system under 16?
schmoo2k wrote: » They should have thought twice before attending the gig then? In your scenario they could have caught it from the vaccinated person beside them...
