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COVID-19: Vaccine/antidote and testing procedures Megathread [Mod Warning - Post #1]

Masala

Today being Paddy Day 2020... when do you think we will have a ‘flu jab’ / pill / syrup that we can take to make us immune/ les likely to catch this 19 virus?.

Mod: The purpose of this thread is baked into the title - COVID-19: Vaccine/antidote and testing procedures - it's not a platform to push an anti vaccination agenda. If posters wish to discuss the perceived cons of vaccinations, or push various theories regarding 'the agenda' (whatever that is supposed to mean), open a thread elsewhere on it.

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Necro

Deleted User wrote: »

Good man. You're a government/big pharma dream citizen.

Mod:

Threadbanned

jobeenfitz

Sconsey wrote: »

I believe that is what phase 4 trials are for....."A type of clinical trial that studies the side effects caused over time by a new treatment after it has been approved and is on the market. These trials look for side effects that were not seen in earlier trials and may also study how well a new treatment works over a long period of time."

So no the data will not include phase 4 trial data but there is nothing unique in the Covid vaccines being approved before phase 4 trials happen.

So right now the long term affects of the vaccine are unknown. Nobody knows.

Im not for or against this vaccine. I'm not against vaccines in general either.

hmmm

jobeenfitz wrote: »

So right now the long term affects of the vaccine are unknown. Nobody knows.

The regulators are looking for 2 months safety data as a minimum after completion of the full course before considering emergency approval.

2 months were picked as a minimum because in the case previously of vaccines with severe side effects (e.g. Guillain-Barré in 1978), these side-effects occurred within weeks of the injection and would be detected by safety monitors.

Emergency use will only be authorised for groups who are at high risk from Covid (e.g. very elderly, front-line care workers). In those cases the risk from Covid is significantly greater than any remaining risk from a vaccine.

What we expect is that regulators will continue to monitor safety data from the trials well beyond the emergency use period, and when satisfied they will authorise the vaccines for groups where they think the safety vs risk is appropriate. There has been some discussion about not vaccinating children, but my understanding is that as more evidence is emerging of older children causing spread and having a low but not insignificant risk from the virus (and the risk of unknown long-term impacts) they are leaning towards vaccinating children.

It's important I think also to remember that vaccinations are only targeting one part of the virus (the spike protein), while a "natural" infection has to do a lot more.

ACitizenErased

Dr. Fauci says it appears Covid strain from Danish mink farms won’t be a problem for vaccines

https://www.cnbc.com/2020/11/13/covid-dr-fauci-says-it-appears-outbreak-in-minks-wont-be-a-problem-for-vaccines.html

ACitizenErased

Not sure if anyone has posted this but Swiss authorities have commenced a rolling review of Moderna's vaccine, whose interim results are likely days away.
https://investors.modernatx.com/news-releases/news-release-details/swissmedic-begins-rolling-review-modernas-mrna-vaccine-against/

Hamsterchops

I grew up with the spectre of Thalidomide in the background, with many expectant mothers given the drug, before the horrific & unexpected side affects!

...hence I'll wait six months before I get my jab.

That's not to say that others should hold back, this is just my own personal decision which is heavily influenced by Thalidomide, which thankfully my Mother refused.

charlie14

jobeenfitz wrote: »

So right now the long term affects of the vaccine are unknown. Nobody knows.

Im not for or against this vaccine. I'm not against vaccines in general either.

The long term effects of catching the damned thing don`t look that happy clappy.

lbj666

Hamsterchops wrote: »

I grew up with the spectre of Thalidomide in the background, with many expectant mothers given the drug, before the horrific & unexpected side affects!

...hence I'll wait six months before I get my jab.

That's not to say that others should hold back, this is just my own personal decision which is heavily influenced by Thalidomide, which thankfully my Mother refused.

Fair enough but, keep in mind that whole shameful history is one of the many reasons for the rigours of drug approvals testing etc nowadays. A side note is that pregnant women with probably be one of the last normally healthy groups to be given the go ahead.

Deeper Blue

ACitizenErased wrote: »

Dr. Fauci says it appears Covid strain from Danish mink farms won’t be a problem for vaccines

https://www.cnbc.com/2020/11/13/covid-dr-fauci-says-it-appears-outbreak-in-minks-wont-be-a-problem-for-vaccines.html

I can hear the distant sound of RTE headline writers sobbing uncontrollably.

Hmmzis

https://www.curevac.com/en/2020/11/12/curevacs-covid-19-vaccine-candidate-cvncov-suitable-for-standard-fridge-temperature-logistics/

CureVac's mRNA vaccine candidate formulation can be stored at regular fridge temps (+5C) for up to 3 months (maybe longer, study still is ongoing). Viable for up to 24h at room temperature.

stephenjmcd

Hmmzis wrote: »

https://www.curevac.com/en/2020/11/12/curevacs-covid-19-vaccine-candidate-cvncov-suitable-for-standard-fridge-temperature-logistics/

CureVac's mRNA vaccine candidate formulation can be stored at regular fridge temps (+5C) for up to 3 months (maybe longer, study still is ongoing). Viable for up to 24h at room temperature.

I've not been keeping too close of an eye on Curevac in the past while. Where are they currently at in terms of readouts etc

ACitizenErased

stephenjmcd wrote: »

I've not been keeping too close of an eye on Curevac in the past while. Where are they currently at in terms of readouts etc

They're in Phase 2A in Panama and Peru, aiming for Phase 2B/3 starting end of this year.

stephenjmcd

ACitizenErased wrote: »

They're in Phase 2A in Panama and Peru, aiming for Phase 2B/3 starting end of this year.

Cheers, looks like AstraZeneca with Oxford and Pfizer with BioNTech will probably be first to market with plenty of other options not far behind

Miike

stephenjmcd wrote: »

I've not been keeping too close of an eye on Curevac in the past while. Where are they currently at in terms of readouts etc

https://www.raps.org/news-and-articles/news-articles/2020/3/covid-19-vaccine-tracker

Pretty decent for keeping up to date with things. They are fast off the mark to edit the table when new data comes

lbj666

https://www.theguardian.com/world/2020/nov/13/is-the-vaccine-safe-do-i-need-it-if-ive-had-covid-readers-questions-answered

Pretty decent Q&A which addresses the less maniacle questions/arguements on the thread the past few days.

JacksonHeightsOwn

Hamsterchops wrote: »

I grew up with the spectre of Thalidomide in the background, with many expectant mothers given the drug, before the horrific & unexpected side affects!

...hence I'll wait six months before I get my jab.

That's not to say that others should hold back, this is just my own personal decision which is heavily influenced by Thalidomide, which thankfully my Mother refused.

You do know the side effects where for a morning sickness treatment don't you, not a vaccine?

Terrible all the same though.

I've full confidence in this upcoming vaccine personally. Medicine has moved on leaps and bounds the past 20 years.

speckle

DSN wrote: »

Think it depends on how much people want to get back to a 'normal' life & attend likes of large gigs, matches, travel etc & I think the vast majority are yearning for this so will do it.

What about those who are vaccines non responders or who are medical unable to have them due to medical issues or reported previous adverse reactions etc? Do they never get to see live music or a play or what about musicians or actors who fall into these catorgories? Very unsound what ticketmaster is proposing at the moment and they could end up being sued. Maybe it is time their monopoly ceased to exist for many reasons

hmmm

speckle wrote: »

What about those who are vaccines non responders or who are medical unable to have them due to medical issues or reported previous adverse reactions etc? Do they never get to see live music or a play or what about musicians or actors who fall into these catorgories? Very unsound what ticketmaster is proposing at the moment and they could end up being sued. Maybe it is time their monopoly ceased to exist for many reasons

In this particular case, people who can't take vaccines it's been said can get tested and prove negative.

Ultimately if you've someone who can't take a vaccine, their protection will come from encouraging as many people as possible who can to actually go and get vaccinated. It's in their interest to encourage massive vaccination uptake as it will reduce their risk.

speckle

just to add somebody mentioned chickenpox earlier... I am wondering if I hold a record.. have had it 4 times!!!!

speckle

hmmm wrote: »

In this particular case, people who can't take vaccines it's been said can get tested and prove negative.

Ultimately if you've someone who can't take a vaccine, their protection will come from encouraging as many people as possible who can to actually go and get vaccinated. It's in their interest to encourage massive vaccination uptake as it will reduce their risk.

I would prefer a good antigen test which are hopefully on their way... and just not go then to a gig etc if infectious and leave my medical history private/GP etc away from a corporate company or to be able to choose when and where I reveal it anonymously. Maybe not everyone would be that responsible though

charlie14

speckle wrote: »

What about those who are vaccines non responders or who are medical unable to have them due to medical issues or reported previous adverse reactions etc? Do they never get to see live music or a play or what about musicians or actors who fall into these catorgories? Very unsound what ticketmaster is proposing at the moment and they could end up being sued. Maybe it is time their monopoly ceased to exist for many reasons

The would not have to be vaccinated. Taking a test and showing they were not positive for the virus would suffice.

BeefeaterHat

El Sueño wrote: »

I can hear the distant sound of RTE headline writers sobbing uncontrollably.

Thank ****

Gael23

Are any of the leading vaccines based on live vectors?

Hmmzis

Gael23 wrote: »

Are any of the leading vaccines based on live vectors?

Live, yes. Replicating, no.

blobert

Quick question on the private side of vaccines.

Have the pharma companies committed to only making their vaccines available to governments to begin with or do they have the option to sell them privately? I saw an article saying they were allowed sell them privately in Australia, nothing about EU.

I'm assuming that if, in parallel with supplying orders from the EU etc Pfizer wanted to sell it's vaccine privately it could make a huge amount of money in doing so.

On top of companies that might want to vaccinate their staff to get them back in an office I'd imagine there are plenty of private individuals who would be willing to pay potentially a large amount of money to receive the vaccine quicker, especially if they were likely to be at the back of the queue/waiting 6 months to a year for the state to supply them with a free vaccine.

Obviously there's ethical questions with this, ie a 50 year old paying €250 to get this quickly is taking a vaccine dose that could be used on a +70 year old (sold for €5), but from the pharma companies perspective there is probably far more money to be made in providing private supply in conjunction with supplying governments.

Anyone have any knowledge of how this is likely to work in the EU? I'd be surprised if there wasn't the option to pay $$$ to get priority access in the US, I suspect they'd have less concerns in this regard.

ShineOn7

Press conference just happened now from the White House completely focused on vaccines

They're confident Moderna is right behind Pfizer in terms of rollout

Trump and Pence even got a round of applause at the end of it :pac:

hmmm

blobert wrote: »

Quick question on the private side of vaccines.

Have the pharma companies committed to only making their vaccines available to governments to begin with or do they have the option to sell them privately? I saw an article saying they were allowed sell them privately in Australia, nothing about EU.

Most of the main manufacturers have taken government money (e.g. Warp speed in the US, German government with Biontech/Pfizer) and that must have come with some conditions. I don't think any of us have seen the contracts that have been signed. The companies probably also don't want the bad press of selling vaccines to billionaires while nurses are getting sick, but I wouldn't be surprised if some went back into the private sector. Once we get past the vaccination of the "vulnerable" I suspect all bets are off.

One thing to remember is that for many of the leading candidates (e.g. Moderna, Pfizer, Oxford) the vaccine platforms themselves are new, and it's the platform which is where they will make their money in time. They can sell a Covid vaccine at cost, and make money when it comes to future products if the platform is proven to work for Covid. I know with Astra Zeneca as an example there is a limit on how long they are required to sell the product at cost, and future booster vaccines (or different vaccines) can be charged at higher prices.

Something like the mRNA platforms are probably going to be future goldmines, and the companies have been able to shave years off the timelines it would have taken them to develop them. It's been a bit of a Manhattan project for vaccines.

Cork2021

Luke O Neill has contacts in Pfizer...

All good news from him.

Also he’s a huge man, dwarfing Tubridy

hmmm

What else did Luke have to say? Also I'm not sure why he seems to be selling bathroom fittings, but I don't watch the LLS myself.

https://twitter.com/annettesphotos/status/1327367754995949572

Cork2021

hmmm wrote: »

What else did Luke have to say? Also I'm not sure why he seems to be selling bathroom fittings, but I don't watch the LLS myself.

https://twitter.com/annettesphotos/status/1327367754995949572

Basically his contact in Pfizer has said safety data will be released next week and that it is safe and expects EUA from both the fda and ema not long after possibly the first week in December. Reckons similar time line for the moderna vaccine. Didn’t mention anything else. One comment he did make from hopefully by summer 21 we’ll be able to nearly fully relax, also said even if restrictions end there will be a lot of hesitant people and we probably won’t see full stadiums or gigs. Oh and needs at least 70% uptake of the vaccines to bring R0 to near 0.2