chrisbonnie wrote: » Cheaper having a fridge than having no patients/residents.
Le Bruise wrote: » But if every person inside the 3 Arena/Aviva has shown that they are either vaccinated/tested negative, then they are no longer super spreader events. If we wait until we have 80% of the population vaccinated before opening up to crowds, there'll be nothing left for the crowds to go to!
hmmm wrote: » We don't know yet how long natural or vaccine-derived immunity will last. There was a concern early on that "mild" Covid infections were not generating longer-term immunity, but I think (I may be wrong) that this is now not considered correct. The most recent peer-reviewed paper which seemed to have good details on immunity suggest that most people maintain immunity for at least 5 months (the length of the study).https://www.sciencedaily.com/releases/2020/10/201028143114.htm "The vast majority of individuals infected with mild-to-moderate COVID 19 mount a robust antibody response that is relatively stable for at least five months, according to research conducted at the Icahn School of Medicine at Mount Sinai and published October 28, in the journal Science. Additionally, the research team found that this antibody response correlates with the body’s ability to neutralize (kill) SARS-CoV-2, the virus that causes COVID-19. "
Hmmzis wrote: » While the study is small, it's very detailed and to the point. The inhibition of germinal centers (GCs) in the majority of natural infections is a rather important finding. Without GCs B cells cannot undergo maturation and cannot differentiate into long lived plasma cells (LLPCs). LLPCs are the ones that migrate to the bone marrow and provide a constant flow of background of antibodies. While an extrafollicular response does give you the same T cells and memory B cells, for them to become active an anamnestic response is required and that can only be triggered by infected cells.
Hmmzis wrote: » As to the estimates for how long vaccine induced protection might last, as I said, there are 'finger in the air' estimates in news articles. We'll only be able to tell for sure in time.
Hmmzis wrote: » Btw. On HPV and HSVs, not sure where you have read that they persist in the bran. They persist in mostly in epithelial cells and their persistence is down to things like inhibition of TLRs, antigen presentation and interferons (among a myriad of other things), they're fascinating little bastards.
CIARAN_BOYLE wrote: » I think we are more likely to bus people to mass vaccination centres or have a mobile clinic than set up freezers capable of - 80 degrees in the nursing homes. It's not an either or.
Although recent studies have hinted that there may be seasonal or daily “circadian” rhythms in our immune function, this hadn’t been confirmed in large numbers of people until now.
ShowMeTheCash wrote: » Yeah this I understand but this study is a mapping natural immune response not vaccine immune response.
And this is where I am at, I was trying to understand how the finger in the air was saying things like 1 - 3 years and would not require a yearly vaccine but on the same hand say natural immunity is very short.
https://www.sciencedaily.com/releases/2018/03/180315093824.htm Well technically nerve cells but the majory of nerve cells are going to reside in the brain and spine.
tobefrank321 wrote: » The odd thing is the same people who are against a vaccine are also against restrictions. But without a vaccine, restrictions are here indefinitely.
lbj666 wrote: » Its going to be a really really slow opening of the tap regarding restrictions. Based on how hospital figures deaths, risk in care homes, risk to immuno comprimised and scale of long covid suffers(which will be watched a lot more from now on) are impacted.
Voltex wrote: » Sputnik V data looking really good too. Not sure how they work out 92% efficacy out of 20 confirmed cases though.https://sputnikvaccine.com/newsroom/pressreleases/the-first-interim-data-analysis-of-the-sputnik-v-vaccine-against-covid-19-phase-iii-clinical-trials-/
Gael23 wrote: » Why should it be once the most vulnerable are vaccinated?
Once the Pfizer coolers reach their destinations, hospitals or pharmacies will have a few choices of how to store the vaccine. The easiest option is using ultracold freezers, but not many sites have them. Otherwise, the facilities can stash the trays in conventional freezers for up to five days. Or they can keep the vials in the cooler for up to 15 days, so long as they replenish the dry ice and don’t open it more than twice a day.
Westernworld. wrote: » I have my own vaccine and it's working well Bleach ,Tequila, THC ,Syrup of Figs and a mystery ingredient
There may be no need to keep the Pfizer vaccine and other similar coronavirus vaccines at -70°C, potentially making it much easier to distribute them across the world. Two other teams using the same mRNA technology for their vaccines have found they remain stable for at least three months in a normal fridge.
ShowMeTheCash wrote: » This may have been covered somewhere else in the thread but I will ask it anyways. So it has been said having covid does not seem to give long term immunity could be as low as 3 months and maybe none at all if a completely different strain of covid.
charlie14 wrote: » From memory I seem to recall that one country (U.K.?) were proposing to use vets to administer these vaccines upon roll-out.
ShowMeTheCash wrote: » "Sinopharm said it anticipates the antibodies from its jab to last between one and three years—although the final result will only be known after the trials."
ShowMeTheCash wrote: » But what is also being said is someone who has recovered from Covid may only see 3 months immunity which is pretty short however the vaccine is going to give people years of immunity?
Hmmzis wrote: » On the treatment side of things:https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(20)30511-7/fulltext Looks like there is a significant improvement with inhalable interferon (79% reduction of severe disease or death and overall ~50% faster recovery). It's interesting that it works even when administered relatively late after symptom onset, 10 days post symptom onset and continued for 14 days thereafter.
Researchers at the University of Pittsburgh School of Medicine describe a new method to extract tiny but extremely powerful SARS-CoV-2 antibody fragments from llamas, which could be fashioned into inhalable therapeutics with the potential to prevent and treat COVID-19.
funnydoggy wrote: » I'm seeing the word "rushed" an awful lot lately. When you try to explain things back, people don't listen. It worries me that we won't have enough vaccinated to hit the herd immunity threshold. I know once the most vulnerable are vaccinated it isn't a HUGE cause for concern but still..
ShineOn7 wrote: » Is this in Irish hospitals yet or will it be soon?
is_that_so wrote: » As one of the UK heads pointed out about clinical trials, it's often about getting the money, something which can really delay phases. They also have high levels of virus prevalence to test against.
