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COVID-19: Vaccine/antidote and testing procedures Megathread [Mod Warning - Post #1]

Masala

Today being Paddy Day 2020... when do you think we will have a ‘flu jab’ / pill / syrup that we can take to make us immune/ les likely to catch this 19 virus?.

Mod: The purpose of this thread is baked into the title - COVID-19: Vaccine/antidote and testing procedures - it's not a platform to push an anti vaccination agenda. If posters wish to discuss the perceived cons of vaccinations, or push various theories regarding 'the agenda' (whatever that is supposed to mean), open a thread elsewhere on it.

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Marhay70

Knex* wrote: »

The one politician with a medical background? Doctor Leo Varadkar?

Should we ask the Healy-Rae's what they think?

I don't question his qualifications, I question his sincerity.

Mars Bar

https://twitter.com/NCEMAUAE/status/1305531641130094597?s=20

ACitizenErased

Mars Bar wrote: »

https://twitter.com/NCEMAUAE/status/1305531641130094597?s=20

Very vague as to what vaccine?

Hmmzis

ACitizenErased wrote: »

Very vague as to what vaccine?

Should be this one:

https://www.fiercebiotech.com/biotech/sinopharm-shares-phase-2-data-inactivated-covid-19-vaccine

It was in phase 3 in UAE since late August. They must have liked what they saw in the trial then.

theguzman

The thing with the vaccine is will we see Varadkar and Micheal Martin getting it? I reckon Varadkar will probably make a twitter video of him getting injected with the vaccine like he did previously getting a HIV/Aid's test. When I see these guys taking it and not dying after then I'll be happy enough to take it myself.

Marhay70

theguzman wrote: »

The thing with the vaccine is will we see Varadkar and Micheal Martin getting it? I reckon Varadkar will probably make a twitter video of him getting injected with the vaccine like he did previously getting a HIV/Aid's test. When I see these guys taking it and not dying after then I'll be happy enough to take it myself.

Tens of thousands of people worldwide have already been given the various vaccines, why do you have to wait for those two before you make up your mind?

Mars Bar

Hmmzis wrote: »

Should be this one:

https://www.fiercebiotech.com/biotech/sinopharm-shares-phase-2-data-inactivated-covid-19-vaccine

It was in phase 3 in UAE since late August. They must have liked what they saw in the trial then.

Few of my neighbours have had the trial. No bother on them at all.

caveat emptor

Hmmzis wrote: »

Not quite, it's a large trial, it's unlikely it'll be stopped entirely with the one severe adverse event. We still don't know if that person was in the vaccine group or the control group.

They were in the vaccine group.

I'm not commenting on how old the news is. I'm informing someone of something they are not aware of
which I hope helps them.

[Deleted User]

caveat emptor wrote: »

They were in the vaccine group.

https://m.youtube.com/watch?v=JdhX-cd8zmc[

Old news, been cleared to resume

ShineOn7

From the daily thread

Sam McConkey p1ssed me off one morning when he was on Radio 1, about a fortnight ago or more, and said that really we couldn't expect a vaccine for 7 years. Whatever our expectations, he really cast the spell of doom that morning.

This fella and RTE are fúcking appalling in all of this

Hmmzis

The Oxford and ICL vaccine candidates will be trialled with the aerosol delivery route:

https://www.imperial.ac.uk/news/203653/landmark-coronavirus-study-trial-inhaled-imperial/

From pre-clinical studies we know that ChAd vectored nasal spray delivered vaccines induce much better IgA (muocosal antibodies). What I haven't seen is an animal study for a nasal/oral spray RNA based vaccine. Very interested how that will work out.

ACitizenErased

Can someone with knowledge of how PCR works clarify something for me?

In De Gascun's twitter thread he spoke about Ireland using a CT amplification between 35 and 45 for the PCR tests. Am I right in saying that anything above 30 will detect even the most miniscule viral quantity and give a positive test result?

[Deleted User]

ACitizenErased wrote: »

Can someone with knowledge of how PCR works clarify something for me?

In De Gascun's twitter thread he spoke about Ireland using a CT amplification between 35 and 45 for the PCR tests. Am I right in saying that anything above 30 will detect even the most miniscule viral quantity and give a positive test result?

I think it depends on the test assay. Either way his point was the test was only suitable as a qualitative yes or no on the presence or not and not a quantitative measure of virus in the sample. In this case a sample may be an old case where dead virus is being detected, or it may be a poorly taken sample where only a tiny amount of virus was swabbed. As the amount of virus in samples will be highly variable due to the nature of the sample collection method it will never be able to distinguish between both

FutureTeashock

AstraZeneca Covid-19 vaccine trial in U.S. on hold

The US has halted the Oxford trials in a damaging blow to efforts to fast track the vaccine! This could prove fatal given the USA's influence on the global stage.:eek:

https://www.cnbc.com/2020/09/14/astrazeneca-covid-19-vaccine-trial-in-us-on-hold-until-at-least-midweek-sources-say.html

[Deleted User]

FutureTeashock wrote: »

AstraZeneca Covid-19 vaccine trial in U.S. on hold

The US has halted the Oxford trials in a damaging blow to efforts to fast track the vaccine! This could prove fatal given the USA's influence on the global stage.:eek:

https://www.cnbc.com/2020/09/14/astrazeneca-covid-19-vaccine-trial-in-us-on-hold-until-at-least-midweek-sources-say.html

In other news, Trump holdings just brought a million shares in Pfizer....

But seriously, the US regulators wanting to look at the data is no surprise given the publicity over this vaccine. The FDA tend to like to see the evidence for themselves

Hmmzis

ACitizenErased wrote: »

Can someone with knowledge of how PCR works clarify something for me?

In De Gascun's twitter thread he spoke about Ireland using a CT amplification between 35 and 45 for the PCR tests. Am I right in saying that anything above 30 will detect even the most miniscule viral quantity and give a positive test result?

Not that very knowledgable on this but from any study I've read that tries to establish a correlate of infection for Ct values, going above 35 would be of questionable utility.

FutureTeashock

Deleted User wrote: »

In other news, Trump holdings just brought a million shares in Pfizer....

But seriously, the US regulators wanting to look at the data is no surprise given the publicity over this vaccine. The FDA tend to like to see the evidence for themselves

Or, a participant developing "a rare spinal inflammatory disorder called transverse myelitis" couldn't just be brushed aside and the safety of the vaccine is clearly in doubt.

Zero chance of a vaccine in 2020, maybe even 2021 in my opinion.

[Deleted User]

FutureTeashock wrote: »

Or, a participant developing "a rare spinal inflammatory disorder called transverse myelitis" couldn't just be brushed aside and the safety of the vaccine is clearly in doubt.

Zero chance of a vaccine in 2020, maybe even 2021 in my opinion.

This will blow your mind...do you know what can sometimes cause acute transverse myelitis -COVID-19.

DrumSteve

FutureTeashock wrote: »

Or, a participant developing "a rare spinal inflammatory disorder called transverse myelitis" couldn't just be brushed aside and the safety of the vaccine is clearly in doubt.

Zero chance of a vaccine in 2020, maybe even 2021 in my opinion.

Trump will ensure that there will be a vaccine this year, come hell or high water.

Whether it works is another thing.

Xtrail14

China would want to pull out their trump card and cash in on their virus with the vaccine.

Sconsey

FutureTeashock wrote: »

Or, a participant developing "a rare spinal inflammatory disorder called transverse myelitis" couldn't just be brushed aside and the safety of the vaccine is clearly in doubt.

Zero chance of a vaccine in 2020, maybe even 2021 in my opinion.

https://covid19vaccinetrial.co.uk/trial-resumes

The independent review process has concluded and following the recommendations of both the independent safety review committee and the UK regulator, the MHRA, the trials will recommence in the UK.

The system works.

An independent review in the UK has said this is not an issue. Your next move is to question the independence of the process or something. The fact that other countries may want to carry out their own investigations is hardly big news.

FutureTeashock

Sconsey wrote: »

https://covid19vaccinetrial.co.uk/trial-resumes

The independent review process has concluded and following the recommendations of both the independent safety review committee and the UK regulator, the MHRA, the trials will recommence in the UK.

The system works.

An independent review in the UK has said this is not an issue. Your next move is to question the independence of the process or something. The fact that other countries may want to carry out their own investigations is hardly big news.

Read the article! This is about the USA. Land of the free, home of the brave.

ACitizenErased

FutureTeashock wrote: »

Read the article! This is about the USA. Land of the free, home of the brave.

You do realise that the FDA stopped the trial as a result of the British event? And will resume by mid-week, once they review the data, just like the British did...........

ACitizenErased

University of Pittsburgh School of Medicine scientists have isolated the smallest biological molecule to date that completely and specifically neutralizes the SARS-CoV-2 virus, which is the cause of COVID-19. This antibody component, which is 10 times smaller than a full-sized antibody, has been used to construct a drug—known as Ab8—for potential use as a therapeutic and prophylactic against SARS-CoV-2.

The researchers report today in the journal Cell that Ab8 is highly effective in preventing and treating SARS-CoV-2 infection in mice and hamsters. Its tiny size not only increases its potential for diffusion in tissues to better neutralize the virus, but also makes it possible to administer the drug by alternative routes, including inhalation. Importantly, it does not bind to human cells—a good sign that it won’t have negative side-effects in people.

https://www.pittwire.pitt.edu/news/pitt-scientists-discover-tiny-antibody-component-highly-effective-preventing-and-treating-sars

Gael23

Can only be good news.
Will that be more on the treatment side of things?

Polar101

Some info on how long it would take to produce vaccines for everyone on the planet. Article is from the Financial Times.

https://www.irishtimes.com/business/health-pharma/not-enough-covid-19-vaccine-for-all-until-2024-says-biggest-producer-1.4354384

the chief executive of the world’s largest vaccine manufacturer has warned that not enough Covid-19 vaccines will be available for everyone in the world to be inoculated until the end of 2024 at the earliest.

Adar Poonawalla, chief executive of the Serum Institute of India, told the Financial Times that pharmaceutical companies were not increasing production capacity quickly enough to vaccinate the global population in less time.

“It’s going to take four to five years until everyone gets the vaccine on this planet,” said Mr Poonawalla, who estimated that if the Covid-19 shot is a two-dose vaccine – such as measles or rotavirus – the world will need 15 billion doses.

Obviously this would be the current situation - it's likely that once an approved vaccine is ready, production can and will be ramped up significantly, and any logistical issues can be sorted out. And he's talking about the population of the entire world, obviously some people will get vaccinated sooner than others.

Thierry12

ACitizenErased wrote: »

University of Pittsburgh School of Medicine scientists have isolated the smallest biological molecule to date that completely and specifically neutralizes the SARS-CoV-2 virus, which is the cause of COVID-19. This antibody component, which is 10 times smaller than a full-sized antibody, has been used to construct a drug—known as Ab8—for potential use as a therapeutic and prophylactic against SARS-CoV-2.

The researchers report today in the journal Cell that Ab8 is highly effective in preventing and treating SARS-CoV-2 infection in mice and hamsters. Its tiny size not only increases its potential for diffusion in tissues to better neutralize the virus, but also makes it possible to administer the drug by alternative routes, including inhalation. Importantly, it does not bind to human cells—a good sign that it won’t have negative side-effects in people.

https://www.pittwire.pitt.edu/news/pitt-scientists-discover-tiny-antibody-component-highly-effective-preventing-and-treating-sars

They found his work?

https://www.bbc.com/news/world-us-canada-52568716

mandrake04

ACitizenErased wrote: »

Can someone with knowledge of how PCR works clarify something for me?

In De Gascun's twitter thread he spoke about Ireland using a CT amplification between 35 and 45 for the PCR tests. Am I right in saying that anything above 30 will detect even the most miniscule viral quantity and give a positive test result?

Most Thermocycle Platforms run between 40-45 Cycles, a positive is detected when you hit the threshold (ie. the point where the Florescence increases exponentially)

Each cycle doubles the amount of copies, if you have absolute minimal amounts of RNA to start with then the Ct is going be high. If you have absolutely no RNA in your system then it wont cross the Negative control.

I give you an example ... and this is just my opinion.

if a patients Ct is 10-20 that's a lot of copies per ml to start with, its a very strong sample. I would say that patients is highly infectious as they have a high concentration of virus so its possible they are replicating and shedding virus. Although this is not a rule its my opinion.

if you are getting close to 30 then you are detecting very low concentration of virus, this could be that you have been infected and recovered and are now clearing the virus.... but it could also be a weak sample because you just been infected and are in the early stages and the virus has not replicated enough in your body to provide a strong result. hence the dilemma.

I would also say there are other factors such as the patient, the quality of the sample taken by the collector etc.

All the test does is detect whether RNA is present or not

I would dismiss anything over 34 as a true positive myself.

JTMan

WSJ update here (paywall) on the Chinese vaccines.

- UAE has approved use of Chinese vaccine for emergency use.
- 3 of 4 Chinese vaccines now approved for emergency use (health care workers mainly) in China.
- China targetting November 2020 or December 2020 for rollout to the public.
- Chinese vaccines likely to give 1-3 years protection.

Gael23

Only in China or worldwide?