Can you think of musical groups, i.e. NOT vocal groups, that do not, or did not when they broke up, have any of their original members left?
The first one that comes to mind is English pub rock/blues group Doctor Feelgood.
Technically, another one is American country rock band Poco as they continued to perform on an ad-hoc basis for a couple of years after their remaining founding member Rusty Young retired.
Any more examples?