Come up with a word that starts and ends with the letters the previous poster provided.
If you can't think of any matches, post a two word phrase (like No Way for N&Y).
Different languages are okay, as long as they are legit words in the language.
If it's absolutely impossible to use the letters, come up with a different pair for the next poster.
(note: be fair, requesting X to start and Q to end does not show your wit
Wheaton's rule applies)
. . . . . . . .
Let's start with...
H & O
(First letter:H Last Letter: O)