Originally Posted by The_Dazzler
Thought this was an interesting article. An out of range d-dimer denotes a poor prognosis. Wonder what the pathophysiology is, is a side effect of COVID-19 due to increased PEs/DVTs? As an aside. I've found the Lancet articles as of late to be top notch.
Re the D-dimer levels
"Contributory mechanisms include systemic pro-inflammatory cytokine responses that are mediators of atherosclerosis directly contributing to plaque rupture through local inflammation, induction of procoagulant factors, and haemodynamic changes, which predispose to ischaemia and thrombosis. In addition, angiotensin converting enzyme 2, the receptor for SARS-CoV-2, is expressed on myocytes and vascular endothelial cells, so there is at least theoretical potential possibility of direct cardiac involvement by the virus."
Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, Xiang J, Wang Y, Song B, Gu X, Guan L. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study.