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A career in biochem?

  • 18-03-2018 4:02pm
    #1
    Registered Users Posts: 176 ✭✭


    Looking for some insights.

    Kind of at a junction - some clarification may be beneficial.

    Without going into a career guidance Q and A - basically, one possible course available to me and, which I have demonstrated to myself I have an interest for - is, biochem.

    Well - technically - it's neuropharmacology, specific to receptor protein binding, neuronal transduction and genetic expression - interference and manipulation of messengers/factors, as a means to modify expression and potentially determine novel means to treat a variety of CNS conditions.

    I guess primarily it would be relative to receptor expression, conformation modification etc.

    The material I've used thus far - has been titled specifically, "molecular neuropharmacology".

    But - it appears a large part of that is dictated by biochemistry; be example, triphosphate recyclicing, kinase activation, g-proteins etc etc.

    When I say, I've demonstrated an interest in this to myself - to me, if I'm willing to set aside my free time, and read text after text (university based literature/books), and enjoy doing it, fascinated by the understanding - that constitutes an interest.
    (In contrast - I attempted computer science - and it was a grind; did not enjoy doing it; thus, did not have an interest here).


    Here's the catch.

    In one sense, I would love to dedicate myself to this discipline - and who knows - make a difference?

    I find drug use fascinating, and discovering the molecular components, in addition to the "ubiquitous", if you will, human impetus to engage in drug use, dissociative properties - the biochemical fundamentals that dictate that physiological outcome - reasoning those components to personalized disposition: like I said, in one way - I would love to throw myself into that area.

    There is a masters program available to me - everything is in place.

    BUT - I formerly graduated in a technical discipline - that I found interesting, mildly.

    When it came down to the work itself, the working life - it was basically so time consuming and overwhelming - I couldn't commit to it.

    I'm not talking about overwhelming in terms of work ethic - but simply - time.


    For me personally - for better or worse - a large part of my life is dedicated to things that many would consider - pass time activities.
    To me - they're essentials.

    They're primarily - sports.
    I see little point in expounding on that but - is what it is. My sports will come before my line of work.

    And in my previous work line - the work conflicted to heavily, and I had to bow out - of the work.


    The alternate option available to me is - physiotherapy.

    I have an interest in this, believe it or no - from getting massage work done - in addition to anatomical understanding from personal training (also a part time PT).

    I've self researched it to some degree and - I know it is a possible career path.

    More than that - I feel unquestionably, I could be a good physio.

    Most importantly - I can decide my own hours, my own clinic - my rules.
    No 8 am to 6 pm plus over time.

    It's a discipline that, I can take at my own pace, my own time; a well respected position/qualification that pays good and I'd enjoy doing; all in all, that's like my dream job.

    **
    Wall of text almost over.

    Here's my question:

    A career in biochem - will it be similar to any other intense cognitive discipline in that - we're talking years of highly intense work, possible research roles, long hours, long weeks - to even gain the degree of competency required to be proficient in the area and make a good living off it??

    I bold that cause - if you want to skip through the jargon - it that basically, what the situation is?

    At a minimum I'm assuming some biochem related position is 9 to 5 type deal, Mon to Fri.

    Can anyone give a little insight into what it's like working in the industry - and/or what one could expect?


Comments

  • Registered Users Posts: 362 ✭✭Fluffybums


    I have a biochem degree and a research based masters. I spent 15 years working for a large pharmacuetical company in their Neuroscience Research Centre in the UK. You can do the 9-5 or a lot more, that depends upon you. I learnt a lot on the job - if you are willing to you can gain so much experience in so many fields. Because we were a basic research lab we were expected to keep on top of the literature relevant to the project you were on. It could be mundane I spent a lot of time on screening assays, but I took the opportunity to engage with molecular modellers, behavioural scientist, electrophysiologist, chemists etc. You get out of it what you put into it. It was hard and I was probably working at the limit of my abilities.

    The problem as far as I can make out is that there is no basic research in the pharma companies in Ireland, it is primarily manufacturing focused. If you want to get into research in pharma you will probably have to leave Ireland.
    You can do 9 to 5, Mon to Fri but don't be surprised if those that are willing to put in more time get on more.


  • Registered Users Posts: 176 ✭✭FakePie


    Fluffybums wrote: »
    I have a biochem degree and a research based masters.  I spent 15 years working for a large pharmacuetical company in their Neuroscience Research Centre in the UK. You can do the 9-5 or a lot more, that depends upon you. I learnt a lot on the job - if you are willing to you can gain so much experience in so many fields.  Because we were a basic research lab we were expected to keep on top of the literature relevant to the project you were on.  It could be mundane I spent a lot of time on screening assays, but I took the opportunity to engage with molecular modellers, behavioural scientist, electrophysiologist, chemists etc.  You get out of it what you put into it.  It was hard and I was probably working at the limit of my abilities.

    The problem as far as I can make out is that there is no basic research in the pharma companies in Ireland, it is primarily manufacturing focused.  If you want to get into research in pharma you will probably have to leave Ireland.
    You can do 9 to 5, Mon to Fri but don't be surprised if those that are willing to put in more time get on more.
    Your job role was primarily assessing assay's?

    Could you expound on your undergrad/post grad background - I assume it was biochem?

    And your own particular interests in the area?
    I assume molecular modelling would be highly set in organic chemistry which - would be another foray for me.

    My primary interests are receptor-protein binding, transduction cascade interference - but I would hope ultimately drug discovery.
    The degree to which that would require understanding molecular C-H based chain structure, is not fully clear to me yet.

    I posted this in a biochem subforum - but primarily because it was the closest in the absence of a pharmacology sub forum; and pharmacology is what I'm looking at.
    Drug mechanics.

    My impression of neuroscience has been, somewhat the exclusion of organic chemistry based material.


    Trying not to ramble - finally - could you give any insights as to remuneration associated with such roles?


  • Registered Users Posts: 176 ✭✭FakePie


    Apologies - you already said biochem degree and research masters.

    Tough area.

    But you'd obviously have extensive insights; as to the comparison of neuropharm with biochem - it seems to me, neuropharm lends highly from principles and insights that are rooted in biochem, as to enzymatic based phosphorylation cascades; but perhaps the latter is more microbial based? Which I'd be steering well clear of.

    I'm just trying to get a sense as to whether I'd be looking at actually molecular chain modification and the accompanying organic chem principles that go along with that.
    Or actually delving deeper into the specifics to receptor-protein binding, conformational changes - that alluded to above.

    I am of the opinion, future drug development will focus on synthesis of more selective agents, targeting perhaps specific subunits on receptor subtypes, or modulatory sites of a given receptor subtypes - fine tuning the cascades and resultant expressions - and then perhaps applying combination techniques to yield a complete outcome - as oppose to the historical multi receptor implicating approach - and all the side effects and cascade cancelling and lack of efficacy etc - that goes along with that.

    There's no question in my mind, that that is the future of drug application.

    I say that as - again - I'm trying to get a sense as to how specifically organic chem principles must be understood and applied, to become proficient in that area.


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