What exactly is happening with AstraZeneca?

Melanchthon · 26-01-2021 08:50PM

But the UK contract was signed three months before the European vaccine deal. So with the UK we have had an extra three months to fix all the glitches we experienced.

From the horse's mouth.

But I guess the posters here that can't say anything at all critical about the EU process will still be calling commentary that the UK is ahead because it got in earlier "fake news".

mick087 · 26-01-2021 08:53PM

brickster69 wrote: »

Astra Zenca's CEO interview

https://www.repubblica.it/cronaca/2021/01/26/news/interview_pascal_soriot_ceo_astrazeneca_coronavirus_covid_vaccines-284349628/

Thanks for the link.

mick087 · 26-01-2021 08:54PM

Melanchthon wrote: »

From the horse's mouth.

But I guess the posters here that can't say anything at all critical about the EU process will still be calling commentary that the UK is ahead because it got in earlier "fake news".

The UK is also having issues getting the vaccine its just they started before us.

26-01-2021 09:06PM

brickster69 wrote: »

Astra Zenca's CEO interview

https://www.repubblica.it/cronaca/2021/01/26/news/interview_pascal_soriot_ceo_astrazeneca_coronavirus_covid_vaccines-284349628/

My folks get their first jab on Thursday. I feel a lot better after reading that.

RobertKK · 26-01-2021 09:11PM

It looks by what the CEO of AstraZeneca is saying that the EMA could approve it for younger people - maybe under 65s rather than older people due to the low number of older people in the trials, along with the wide confidence internal, even though AZ say they are confident in it for the elderly.

Wolf359f · 26-01-2021 09:13PM

mick087 wrote: »

Its also been said that doing this way you will get a better results with the lasting effect having a longer protection with antibodies.

So with Oxford one they tested different weeks apart and data was shown 12 weeks apart bumps up to more than 90% effective Parts of Canada are now doing it this way.

There was no testing on pfizer except for 3 weeks apart.

The vaccines are in early days

Has Canada even approved the Oxford vaccine?

Doc07 · 26-01-2021 09:20PM

RobertKK wrote: »

It looks by what the CEO of AstraZeneca is saying that the EMA could approve it for younger people - maybe under 65s rather than older people due to the low number of older people in the trials, along with the wide confidence internal, even though AZ say they are confident in it for the elderly.

Not quite, he’s saying some countries may chose to use it in younger populations in their programs. EMA can still give an approval applicable to all adults and the data (or lack of) for older people can be represented.
If Pfizer and Moderna had not successfully recruited large number of older people in the trials, as long as overall efficacy was good (and it was very good) then they also could have still applied for an all adult approval.

brickster69 · 26-01-2021 09:20PM

Wolf359f wrote: »

Has Canada even approved the Oxford vaccine?

Not yet. They are up in arms ATM because they were told by Pfizer they would be getting 0% of it's vaccine contracted order this week ( they get it from the Belgium site )

The EU received 98% of it's order though.:eek:

Donald Trump · 26-01-2021 09:45PM

Melanchthon wrote: »

From the horse's mouth.

But the UK contract was signed three months before the European vaccine deal. So with the UK we have had an extra three months to fix all the glitches we experienced.

But I guess the posters here that can't say anything at all critical about the EU process will still be calling commentary that the UK is ahead because it got in earlier "fake news".

Have a think about what you are saying there when you believe that. Seems like waffle from him tbh

They were able to work out the vaccine production glitches for the UK because they ordered them three months earlier.
But they still haven't been able to work out how to fix the vaccine production glitches for the EU.

If true, do you not think that a big company like that would advise one team to let the other team know what worked? UK is getting the same vaccine as the EU.
Maybe even now, instead of the EU-destined vaccine production team still trying to reinvent the wheel over the next few weeks, they might be able to ask the lads who figured it out a few months back for the UK?

Melanchthon · 26-01-2021 10:07PM

Donald Trump wrote: »

If true, do you not think that a big company like that would advise one team to let the other team know what worked? UK is getting the same vaccine as the EU.
Maybe even now, instead of the EU-destined vaccine production team still trying to reinvent the wheel over the next few weeks, they might be able to ask the lads who figured it out a few months back for the UK?

Isn't biological process engineering hard and finicky though, like not my area at all but sure somebody here has experience with big bioreactors.

In terms of the interview in as a whole I am more skeptical after spotting that he conflated the UK emergency approval with full approval by a hard regulator, I could be wrong but think the UK is still operating under emergency approval.

Donald Trump · 26-01-2021 10:16PM

Melanchthon wrote: »

Isn't biological process engineering hard and finicky though, like not my area at all but sure somebody here has experience with big bioreactors.

In terms of the interview in as a whole I am more skeptical after spotting that he conflated the UK emergency approval with full approval by a hard regulator, I could be wrong but think the UK is still operating under emergency approval.

If the EU signed three months after the UK, then that means that AZ had three months more information when agreeing to whatever terms were in the EU contract.

Frank Bullitt · 26-01-2021 10:20PM

brickster69 wrote: »

Not yet. They are up in arms ATM because they were told by Pfizer they would be getting 0% of it's vaccine contracted order this week ( they get it from the Belgium site )

The EU received 98% of it's order though.:eek:

https://twitter.com/JustinTrudeau/status/1354190321681371141

Tough few weeks for poor Justin it seems, he has to do a lot of face saving these days.

BoatMad · 26-01-2021 10:23PM

[Deleted User] wrote: »

I'm kind of wondering if AZ had done some of the at risk manufacturing, but were peeved by the EMA's comments over Christmas that better data was needed, so they decided EMA approval was going to take longer than they had originally anticipated and shipped what they had made elsewhere where approval was closer or granted. Thinking they could catch up by the time EMA approval came through.

Yes from sources I know , Astra entered into contractual arrangements because of the approval delays and are now overcommitted.

It’s not a production issue.

But I understand the EMA delays let Astra off the hook contractually

brickster69 · 26-01-2021 10:26PM

Great to see the poorer countries getting supplies through now.

Morocco starts distributing vaccines to 3,000 locations in Africa’s first rollout of a MASS Covid-19 immunisation. It has received 2 million doses of the AstraZeneca & expects 500,000 doses from China's Sinopharm tomorrow. Foreign residents will also receive the vaccine free.

BoatMad · 26-01-2021 10:27PM

Melanchthon wrote: »

Isn't biological process engineering hard and finicky though, like not my area at all but sure somebody here has experience with big bioreactors.

In terms of the interview in as a whole I am more skeptical after spotting that he conflated the UK emergency approval with full approval by a hard regulator, I could be wrong but think the UK is still operating under emergency approval.

The EMA was based in the U.K. and relied heavily on U.K. domestic resources the U.K. is a leading resource in this area

The Ema hurriedly relocated to Amsterdam loosing valuable corporate resources along the way. It’s being trying to recover ever since.

The uk approved the vaccine under existing EU emergency laws. Any EU country could have done the same.

Nothing hard or soft about it.

26-01-2021 10:38PM

BoatMad wrote: »

The EMA was based in the U.K. and relied heavily on U.K. domestic resources the U.K. is a leading resource in this area

The Ema hurriedly relocated to Amsterdam loosing valuable corporate resources along the way. It’s being trying to recover ever since.

The uk approved the vaccine under existing EU emergency laws. Any EU country could have done the same.

Nothing hard or soft about it.

With regards the Oxford vaccine though, they were pretty much embedded in the trials from what I understand. They provided funding right from the start so could get the data more or less when it was available rather than waiting for a final report.

BoatMad · 26-01-2021 10:47PM

Aegir wrote: »

With regards the Oxford vaccine though, they were pretty much embedded in the trials from what I understand. They provided funding right from the start so could get the data more or less when it was available rather than waiting for a final report.

It’s the U.K. regulator was deeply involved right from the start

Of course the EMA “ is applying its normal standards to this approval “

Err have you looked out the window EMA.

26-01-2021 10:59PM

BoatMad wrote: »

It’s the U.K. regulator was deeply involved right from the start

Of course the EMA “ is applying its normal standards to this approval “

Err have you looked out the window EMA.

I should have made that clearer, yes the U.K. regulator.

Actually, it was the UK’s vaccine task force that seeded several programmes very early doors. It took a lot of criticism at the time as it was headed by the wife of a Tory junior minister, who just so happened to be a partner in a private equity firm that specialises in this very area.

Dyr · 26-01-2021 11:00PM

Bit weird with all the crowing that was going on about how the brits would be out in the cold for medical supplies to see them doing quiet well in comparison to the EU

BoatMad · 26-01-2021 11:01PM

Aegir wrote: »

I should have made that clearer, yes the U.K. regulator.

Actually, it was the UK’s vaccine task force that seeded several programmes very early doors. It took a lot of criticism at the time as it was headed by the wife of a Tory junior minister, who just so happened to be a partner in a private equity firm that specialises in this very area.

The EU EMA is totally unsuited to the process it’s engaged in.

It’s needs to be overruled.

The Germans in my opinion will do an emergency approval rumour has it they have a side deal with Astra.

Eu solidarity will go out the window as it becomes clear Astra has no product for the EU

BoatMad · 26-01-2021 11:03PM

Bambi wrote: »

Bit weird with all the crowing that was going on about how the brits would be out in the cold for medical supplies to see them doing quiet well in comparison to the EU

Quite well , they are 4x ahead with a national source of Astra supply available

The EU commission screwed up and it’s anger is hiding the fact it’s knows this will be a huge scandal

26-01-2021 11:06PM

BoatMad wrote: »

The EU EMA is totally unsuited to the process it’s engaged in.

It’s needs to be overruled.

The Germans in my opinion will do an emergency approval rumour has it they have a side deal with Astra.

Eu solidarity will go out the window as it becomes clear Astra has no product for the EU

Germany ignored the EU’s grand vaccination roll out show of solidarity by starting a day early. Seems they are happy to put pragmatism over politics.

https://www.rte.ie/news/coronavirus/2020/1226/1186491-coronavirus-europe-vaccine/

Qiaonasen · 26-01-2021 11:09PM

political analyst wrote: »

But China has its own vaccines, doesn't it?

They don't appear to work. They haven't published any data in legitimate journals and studies in Brazil show just 50% efficacy. But China has 1.5 Billion people and that won't end the pandemic. They'll still be buying other vaccines.

political analyst · 26-01-2021 11:42PM

Aegir wrote: »

Germany ignored the EU’s grand vaccination roll out show of solidarity by starting a day early. Seems they are happy to put pragmatism over politics.

https://www.rte.ie/news/coronavirus/2020/1226/1186491-coronavirus-europe-vaccine/

What difference to 24 hours make in this situation?! :rolleyes:

MrMusician18 · 27-01-2021 01:25AM

BoatMad wrote: »

The EU EMA is totally unsuited to the process it’s engaged in.

It’s needs to be overruled.

The Germans in my opinion will do an emergency approval rumour has it they have a side deal with Astra.

Eu solidarity will go out the window as it becomes clear Astra has no product for the EU

What difference will a side deal make when AZ have said that the issues are manufacturing related. An emergency german approval is of no use if AZ do not have the capability to deliver. Which seemingly they don't.

Given that AZ approval is expected at the end of the week, why would the Germans break rank now, so late in the day?

Many aspects of your posts make little sense tbh.

IRISHSPORTSGUY · 27-01-2021 08:01AM

brickster69 wrote: »

Astra Zenca's CEO interview

https://www.repubblica.it/cronaca/2021/01/26/news/interview_pascal_soriot_ceo_astrazeneca_coronavirus_covid_vaccines-284349628/

He is being slightly disingenuous...

https://www.astrazeneca.com/media-centre/press-releases/2020/astrazeneca-to-supply-europe-with-up-to-400-million-doses-of-oxford-universitys-vaccine-at-no-profit.html

https://ec.europa.eu/commission/presscorner/detail/en/ip_20_1524

The agreement was reached 1 month after the UK, but the contract was rubber stamped by the EU in August (3 months).
Still, it gave him/AZ the legal leeway to divert supply to Britain from the manufacturing plants on the continent.

McGiver · 27-01-2021 09:00AM

Aegir wrote:

as far as we know based on what?

Brexiters can't open the EU commission website?

Press statement by Commissioner Kyriakides on vaccine deliveries and on the vaccine export transparency scheme

Yesterday evening, Commissioner Stella Kyriakides made the following statement: "You know that AstraZeneca's vaccine is currently in the final stages of the approval process with the European Medicines Agency. If all requirements are met, the European Medicines Agency could recommend market authorisation by the end of this week. But there is a problem on the supply side. Last Friday, the company AstraZeneca surprisingly informed the Commission and the European Union Member States that it intends to supply considerably fewer doses in the coming weeks than agreed and announced. This new schedule is not acceptable to the European Union. That is why I wrote a letter to the company at the weekend in which I asked important and serious questions. The European Union has pre-financed the development of the vaccine and the production and wants to see the return. The European Union wants to know exactly which doses have been produced by AstraZeneca and where exactly so far and if or to whom they have been delivered. These questions were also discussed today in the joint Steering Board of the Commission and the 27 Member States with AstraZeneca. The answers of the company have not been satisfactory so far. That's why a second meeting is scheduled for tonight.The European Union wants the ordered and pre-financed doses to be delivered as soon as possible. And we want our contract to be fully fulfilled. In addition, the Commission has today proposed to the 27 Member States in the Steering Board that an export transparency mechanism will be put in place as soon as possible. The European Union has supported the rapid development and production of several vaccines against COVID-19 with a total of €2.7 billion. We want clarity on transactions and full transparency concerning the export of vaccines from the EU. In the future, all companies producing vaccines against COVID-19 in the EU will have to provide early notification whenever they want to export vaccines to third countries. Humanitarian deliveries are of course not affected by this. The European Union will take any action required to protect its citizens and rights." This statement is available online here and can also be watched on EbS. (For more information: Stefan De Keersmaecker Tel.: +32 229 84680; Darragh Cassidy Tel.: +32 229 83978)

https://ec.europa.eu/commission/presscorner/detail/en/SPEECH_21_211

You may wish to call Mr Keersmaecker if unsure.

The above press release I hope stops these speculations. We the EU, funded development of the AZ vaccine, we signed a contract and preordered 300M doses. AZ is now reneging on that contract. End of the story.

mick087 · 27-01-2021 09:02AM

The EU have simpley let its citizens down.
When other countries was ordering the EU was negotiating a deal for a vaccine being made not for profit.
Even though this vaccine was cheap they still needed to be seen to be getting a better deal.
Even now this Oxford vaccine has still not been approved by the EU.
They are having a meeting Friday to discuss .What are these people doing?

We are 3 months behind the UK in buying the vaccine this is simlply just not good enough.

The factory is moving location there is no conspiracy theories no other country is getting our share. All other countries will also face a delay.

The EU was slow to order and now slow to approve its use.
Once again there is no accountability from the EU selected commission. Everyone else is to blame but them, A total utter shambles.

McGiver · 27-01-2021 09:09AM

mick087 wrote: »

The EU have simpley let its citizens down.
When other countries was ordering the EU was negotiating a deal for a vaccine being made not for profit.
Even though this vaccine was cheap they still needed to be seen to be getting a better deal.
Even now this Oxford vaccine has still not been approved by the EU.
They are having a meeting Friday to discuss .What are these people doing?

We are 3 months behind the UK in buying the vaccine this is simlply just not good enough.

The factory is moving location there is no conspiracy theories no other country is getting our share. All other countries will also face a delay.

The EU was slow to order and now slow to approve its use.
Once again there is no accountability from the EU selected commission. Everyone else is to blame but them, A total utter shambles.

Give me officially sources else I report you for trolling.

Blazer · 27-01-2021 09:11AM

McGiver wrote: »

Give me officially sources else I report you for trolling.

Its the daily mail don't you know.. that's exactly the ****e they printed to appeal to dumb brits.

What exactly is happening with AstraZeneca?

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