Choice of Vaccine

Danno

In a hypothetical world where there is an abundance of supply of every brand, all of which are approved, and your vaccine appointment is now due. You are asked which vaccine would you like to take or even not take any? And why?

In an ideal world, vaccines with the highest effectiveness going to those who need them most. I'm healthy and under forty, if supply and demand were an issue I would go for lower end of efficacy scale.

Danno

Deleted User wrote: »

In an ideal world, vaccines with the highest effectiveness going to those who need them most. I'm healthy and under forty, if supply and demand were an issue I would go for lower end of efficacy scale.

Which brand would that be?

Danno

Danno wrote: »

Which brand would that be?

Smiley smile aka Luke O'Neill has sold me on the merits of Sputnik V. Fringe benefits include becoming a multi-millionaire with a podcast overnight.

Tippbhoy1

Danno wrote: »

In a hypothetical world where there is an abundance of supply of every brand, all of which are approved, and your vaccine appointment is now due. You are asked which vaccine would you like to take or even not take any? And why?

Pfizer.
It’s in the most arms, best production to date, seems to have the least side effects, and has the best reported efficacy.

Atlantic Dawn

Pfizer now would be by choice as have heard pain/reaction is less than the AZ but I'd go with the J&J one shot once that's available as one needle in the arm is enough for me.

astrofool

Whichever I was offered first.

Straight choice, in order, Pfizer, Moderna, J&J, Sputnik, AZ.

99nsr125

Danno wrote: »

In a hypothetical world where there is an abundance of supply of every brand, all of which are approved, and your vaccine appointment is now due. You are asked which vaccine would you like to take or even not take any? And why?

Sinovac

It's an old school inactivated viral particle

granturismo

99nsr125 wrote: »

Sinovac

It's an old school inactivated viral particle

I may have the theory on the vaccines flawed but if Sinovac has the whole inactivated virus, in theory is should be more robust to future covid mutations. The current vaccines only have part of the virus particle or partial mRNA - if a mutation was to appear in one of these sections the whole inactivated viral particle seems to offer better future protection.

Is it a sort of a shotgun approach rather than a precise sniper. I dont trust any data coming out of China but what do they claim on efficacy?

Polar101

I'd be pretty happy with any of AZ/Pfizer/Moderna (or J&J). I don't really mind as long it's not Sputnik or any of the Chinese ones.

Markus Antonius

I'm going to ask my GP if there is a gluten free option

hmmm

Doesn't matter, they'll all stop you from dying. The efficacy results are hard to compare, they all measured slightly different things and the trials were run in different countries with different variants. A few weeks ago we thought that the Oxford vaccine was one of the less effective ones, now the data coming out of the UK suggests it's one of the most effective ones.

JacksonHeightsOwn

Couldn't care less which one I get, Pfizer, moderna, AZ, sputnik.

I'll pull my t-shirt up for any one of them.

robindch

Danno wrote: »

In a hypothetical world where there is an abundance of supply of every brand, all of which are approved, and your vaccine appointment is now due. You are asked which vaccine would you like to take or even not take any? And why?

Firstly, I would spend a couple of minutes searching for reliable efficacy results from high-impact, peer-reviewed scientific journals - of which The Lancet and the New England Journal of Medicine (NEJM) are two.

Having done just that, and assuming that the people providing the vaccine select the optimal dosage plan, here are the results:

94.1% - Moderna - NEJM paper here.

90.5% - Pfizer/BioNTech (BNT162b2) - Lancet paper here,

90·0% - AstraZeneca (ChAdOx1) - Lancet paper here. Note that normal first and second dose gave 62.1% efficacy, but giving a lower first dose and a higher second dose produced 90.0% efficacy. Average efficacy of both sets was 70.4%.

On the basis of the above, the Moderna vaccine is best, followed by the Pfizer/BioNTech vaccine, then the AstraZeneca vaccine.

That said, they're all pretty good and if offered any of them, I would have no hesitation in taking what I was offered.

Chivito550

robindch wrote: »

Firstly, I would spend a couple of minutes searching for reliable efficacy results from high-impact, peer-reviewed scientific journals - of which The Lancet and the New England Journal of Medicine (NEJM) are two.

Having done just that, and assuming that the people providing the vaccine select the optimal dosage plan, here are the results:

94.1% - Moderna - NEJM paper here.

90.5% - Pfizer/BioNTech (BNT162b2) - Lancet paper here,

90·0% - AstraZeneca (ChAdOx1) - Lancet paper here. Note that normal first and second dose gave 62.1% efficacy, but giving a lower first dose and a higher second dose produced 90.0% efficacy. Average efficacy of both sets was 70.4%.

On the basis of the above, the Moderna vaccine is best, followed by the Pfizer/BioNTech vaccine, then the AstraZeneca vaccine.

That said, they're all pretty good and if offered any of them, I would have no hesitation in taking what I was offered.

I got AZ today and I was told 76% after first dose, then second dose brings it up to 83%.

Chivito550

Chivito550 wrote: »

I got AZ today and I was told 76% after first dose, then second dose brings it up to 83%.

Still pretty decent! How's yer arm? My mother got hers (AZ) in the UK there a couple of weeks ago and said her arm was killing in the night but she's been fine since.

Rodin

We need to take whatever's going.
We're woefully far behind the UK.

Will be months before any meaningful lifting of restrictions.

Chivito550

[Deleted User] wrote: »

Still pretty decent! How's yer arm? My mother got hers (AZ) in the UK there a couple of weeks ago and said her arm was killing in the night but she's been fine since.

Arm is fine. A sudden jetlag type feeling came on me this evening out of nowhere, but felt surprisingly better after a couple bottles of beer. Hoping I'll wake up fine tomorrow. The day after is supposedly when the worst symptoms hit.

fits

Honestly I’d take any that has been approved by EMA. Don’t have any preference at all.

Eric Cartman

The sputnik one is the only one I wont touch, id be suspicious of russias claimed effectiveness rate and also reluctant to fund that dictatorship

landofthetree

As I'm not at high risk from Covid I will go for the one that reduces transmission the most.

Thelonious Monk

My friend in Malta got the AZ one the other day and felt sick for a day or two. He and my brother both live there and have already been vaccinated, even though they are blow ins, and the whole time you could still get a beer or go to the gym.
How the f*ck is it so poorly managed here?

JP Liz V1

Atlantic Dawn wrote: »

Pfizer now would be by choice as have heard pain/reaction is less than the AZ but I'd go with the J&J one shot once that's available as one needle in the arm is enough for me.

I'm not keen on AZ but it depends what my GP offers, it would be nice to choose

ddarcy

Chivito550 wrote: »

I got AZ today and I was told 76% after first dose, then second dose brings it up to 83%.

The US clinical trial has 76% for two doses. It’s being heavily criticised right now, so could be lower. Having worked with the FDA and EMA, I’ll trust the FDA any day of the week over the eMA results. It’s one of the few things the US gets right (the US has very rigorous standards and procedures to follow, more so than Europe). I’m waiting on their submission to the FDA to have a read.

titan18

Probably Pfizer, Moderns, J&J and then AZ as the ones I'd least like by a mile.

ceadaoin.

Danno wrote: »

In a hypothetical world where there is an abundance of supply of every brand, all of which are approved, and your vaccine appointment is now due. You are asked which vaccine would you like to take or even not take any? And why?

This isn't a hypothetical world here in the US. I can walk into a pharmacy tomorrow and get vaccinated if I so choose, with Pfizer, Moderna or J&J. Only J&J for me though just because its only 1 shot and a more traditional type of vaccine, so I would book a place that is offering that one. I will only do it if it makes travelling easier, given my age and risk profile for covid.

Russman

ceadaoin. wrote: »

This isn't a hypothetical world here in the US. I can walk into a pharmacy tomorrow and get vaccinated if I so choose, with Pfizer, Moderna or J&J. Only J&J for me though just because its only 1 shot and a more traditional type of vaccine, so I would book a place that is offering that one. I will only do it if it makes travelling easier, given my age and risk profile for covid.

Out of curiosity, do you need any documentation to do this, or can anyone walk in and get a jab ? If a tourist were to find themselves in the States could they rock up and get vaccinated in a pharmacy ?

theguzman

I will be getting vaccinated privately outside of Ireland next week, I have a choice of Pfizer/BioNtech, AstraZeneca, Sputnik V and BBIBP-CorV the Chinese Sinopharm COVID-19 vaccine. Right now I am undecided between Sputnik V and Pfizer/BioNtech, I won't take AZ or the Chinese one. I'm hoping for Pfizer but honestly I have great faith in Sputnik V also. I'm in my mid thirties with no underlying condition and I think the HSE has made a dogs dinner of the rollout at home and the Govt could not have made a worse job of everything if they tried.

ceadaoin.

Russman wrote: »

Out of curiosity, do you need any documentation to do this, or can anyone walk in and get a jab ? If a tourist were to find themselves in the States could they rock up and get vaccinated in a pharmacy ?

You need ID, and when it was restricted to certain groups, like casino workers or those with underlying conditions, you had to show proof that you were in that category. Now it's open to anyone over 16. I'd imagine though that they wouldn't really care if you showed them a foreign passport, I mean you could be an immigrant who hasn't got their drivers license sorted yet.

biko

I would probably go with Sputnik if it was available.

Pfizer, Moderna or J&J. Basically any approved vaccine other than AZ.

astrofool

biko wrote: »

I would probably go with Sputnik if it was available.

From the Slovak supply, of course.

FileNotFound

Once they have had time to look into the AZ issues it may be easy to identify the casual factors.

If you have face fillers Moderna can give you Bells Palsy, no issue for anyone with the natural look.

AZ clotting issue, I heard it is more common in females near 30? If something like this is true and they can identify risk v non risk groups, it will just be a case of higher risk not getting it.

Pfizer seems to be going well.

J&J would be my pref just because it's a 1 shot.

But assuming they figure out causal for AZ blood clotting and I'm not at risk I'd be happy with any.

RCK1

The best vaccine is the one one which is in your arm.

If I had a choice it be Pfizer as it seems to be doing the best at the moment or else Johnson+Johnson just for the pure convenience of the one shot

biko

astrofool wrote: »

From the Slovak supply, of course.

Wouldn't have it any other way

Gregor Samsa

Not pushed which one I get, but if they were all in front of me and I had to choose, I'd go with J&J for the one shot.