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Choice of Vaccine

  • 04-03-2021 11:42pm
    #1
    Registered Users Posts: 8,097 ✭✭✭ Danno


    In a hypothetical world where there is an abundance of supply of every brand, all of which are approved, and your vaccine appointment is now due. You are asked which vaccine would you like to take or even not take any? And why?


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Comments

  • Registered Users Posts: 5,423 ✭✭✭ Berties_Horse


    In an ideal world, vaccines with the highest effectiveness going to those who need them most. I'm healthy and under forty, if supply and demand were an issue I would go for lower end of efficacy scale.


  • Registered Users Posts: 8,097 ✭✭✭ Danno


    In an ideal world, vaccines with the highest effectiveness going to those who need them most. I'm healthy and under forty, if supply and demand were an issue I would go for lower end of efficacy scale.
    Which brand would that be?


  • Registered Users Posts: 5,423 ✭✭✭ Berties_Horse


    Danno wrote: »
    Which brand would that be?

    Smiley smile aka Luke O'Neill has sold me on the merits of Sputnik V. Fringe benefits include becoming a multi-millionaire with a podcast overnight.


  • Registered Users Posts: 155 ✭✭ Tippbhoy1


    Danno wrote: »
    In a hypothetical world where there is an abundance of supply of every brand, all of which are approved, and your vaccine appointment is now due. You are asked which vaccine would you like to take or even not take any? And why?

    Pfizer.
    It’s in the most arms, best production to date, seems to have the least side effects, and has the best reported efficacy.


  • Registered Users Posts: 72,022 ✭✭✭✭ Atlantic Dawn


    Pfizer now would be by choice as have heard pain/reaction is less than the AZ but I'd go with the J&J one shot once that's available as one needle in the arm is enough for me.


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  • Registered Users Posts: 14,738 ✭✭✭✭ astrofool


    Whichever I was offered first.

    Straight choice, in order, Pfizer, Moderna, J&J, Sputnik, AZ.


  • Registered Users Posts: 1,184 ✭✭✭ 99nsr125


    Danno wrote: »
    In a hypothetical world where there is an abundance of supply of every brand, all of which are approved, and your vaccine appointment is now due. You are asked which vaccine would you like to take or even not take any? And why?

    Sinovac

    It's an old school inactivated viral particle


  • Registered Users Posts: 1,787 ✭✭✭ granturismo


    99nsr125 wrote: »
    Sinovac

    It's an old school inactivated viral particle

    I may have the theory on the vaccines flawed but if Sinovac has the whole inactivated virus, in theory is should be more robust to future covid mutations. The current vaccines only have part of the virus particle or partial mRNA - if a mutation was to appear in one of these sections the whole inactivated viral particle seems to offer better future protection.

    Is it a sort of a shotgun approach rather than a precise sniper. I dont trust any data coming out of China but what do they claim on efficacy?


  • Registered Users Posts: 3,212 ✭✭✭ Polar101


    I'd be pretty happy with any of AZ/Pfizer/Moderna (or J&J). I don't really mind as long it's not Sputnik or any of the Chinese ones.


  • Registered Users Posts: 1,179 ✭✭✭ Markus Antonius


    I'm going to ask my GP if there is a gluten free option


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  • Moderators, Sports Moderators Posts: 11,205 Mod ✭✭✭✭ hmmm


    Doesn't matter, they'll all stop you from dying. The efficacy results are hard to compare, they all measured slightly different things and the trials were run in different countries with different variants. A few weeks ago we thought that the Oxford vaccine was one of the less effective ones, now the data coming out of the UK suggests it's one of the most effective ones.


  • Registered Users Posts: 1,885 ✭✭✭ JacksonHeightsOwn


    Couldn't care less which one I get, Pfizer, moderna, AZ, sputnik.

    I'll pull my t-shirt up for any one of them.


  • Moderators, Society & Culture Moderators Posts: 24,255 Mod ✭✭✭✭ robindch


    Danno wrote: »
    In a hypothetical world where there is an abundance of supply of every brand, all of which are approved, and your vaccine appointment is now due. You are asked which vaccine would you like to take or even not take any? And why?
    Firstly, I would spend a couple of minutes searching for reliable efficacy results from high-impact, peer-reviewed scientific journals - of which The Lancet and the New England Journal of Medicine (NEJM) are two.

    Having done just that, and assuming that the people providing the vaccine select the optimal dosage plan, here are the results:

    94.1% - Moderna - NEJM paper here.

    90.5% - Pfizer/BioNTech (BNT162b2) - Lancet paper here,

    90·0% - AstraZeneca (ChAdOx1) - Lancet paper here. Note that normal first and second dose gave 62.1% efficacy, but giving a lower first dose and a higher second dose produced 90.0% efficacy. Average efficacy of both sets was 70.4%.

    On the basis of the above, the Moderna vaccine is best, followed by the Pfizer/BioNTech vaccine, then the AstraZeneca vaccine.

    That said, they're all pretty good and if offered any of them, I would have no hesitation in taking what I was offered.


  • Registered Users Posts: 7,686 ✭✭✭ Chivito550


    robindch wrote: »
    Firstly, I would spend a couple of minutes searching for reliable efficacy results from high-impact, peer-reviewed scientific journals - of which The Lancet and the New England Journal of Medicine (NEJM) are two.

    Having done just that, and assuming that the people providing the vaccine select the optimal dosage plan, here are the results:

    94.1% - Moderna - NEJM paper here.

    90.5% - Pfizer/BioNTech (BNT162b2) - Lancet paper here,

    90·0% - AstraZeneca (ChAdOx1) - Lancet paper here. Note that normal first and second dose gave 62.1% efficacy, but giving a lower first dose and a higher second dose produced 90.0% efficacy. Average efficacy of both sets was 70.4%.

    On the basis of the above, the Moderna vaccine is best, followed by the Pfizer/BioNTech vaccine, then the AstraZeneca vaccine.

    That said, they're all pretty good and if offered any of them, I would have no hesitation in taking what I was offered.

    I got AZ today and I was told 76% after first dose, then second dose brings it up to 83%.


  • Registered Users Posts: 949 ✭✭✭ Cymro


    Chivito550 wrote: »
    I got AZ today and I was told 76% after first dose, then second dose brings it up to 83%.

    Still pretty decent! How's yer arm? My mother got hers (AZ) in the UK there a couple of weeks ago and said her arm was killing in the night but she's been fine since.


  • Registered Users Posts: 3,130 ✭✭✭ Rodin


    We need to take whatever's going.
    We're woefully far behind the UK.

    Will be months before any meaningful lifting of restrictions.


  • Registered Users Posts: 7,686 ✭✭✭ Chivito550


    Cymro wrote: »
    Still pretty decent! How's yer arm? My mother got hers (AZ) in the UK there a couple of weeks ago and said her arm was killing in the night but she's been fine since.

    Arm is fine. A sudden jetlag type feeling came on me this evening out of nowhere, but felt surprisingly better after a couple bottles of beer. Hoping I'll wake up fine tomorrow. The day after is supposedly when the worst symptoms hit.


  • Registered Users Posts: 12,270 ✭✭✭✭ fits


    Honestly I’d take any that has been approved by EMA. Don’t have any preference at all.


  • Registered Users Posts: 26,407 ✭✭✭✭ Eric Cartman


    The sputnik one is the only one I wont touch, id be suspicious of russias claimed effectiveness rate and also reluctant to fund that dictatorship


  • Registered Users Posts: 2,203 ✭✭✭ landofthetree


    As I'm not at high risk from Covid I will go for the one that reduces transmission the most.


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  • Registered Users Posts: 10,428 ✭✭✭✭ Thelonious Monk


    My friend in Malta got the AZ one the other day and felt sick for a day or two. He and my brother both live there and have already been vaccinated, even though they are blow ins, and the whole time you could still get a beer or go to the gym.
    How the f*ck is it so poorly managed here?


  • Registered Users Posts: 74,967 ✭✭✭✭ JP Liz V1


    Pfizer now would be by choice as have heard pain/reaction is less than the AZ but I'd go with the J&J one shot once that's available as one needle in the arm is enough for me.

    I'm not keen on AZ but it depends what my GP offers, it would be nice to choose


  • Registered Users Posts: 558 ✭✭✭ ddarcy


    Chivito550 wrote: »
    I got AZ today and I was told 76% after first dose, then second dose brings it up to 83%.

    The US clinical trial has 76% for two doses. It’s being heavily criticised right now, so could be lower. Having worked with the FDA and EMA, I’ll trust the FDA any day of the week over the eMA results. It’s one of the few things the US gets right (the US has very rigorous standards and procedures to follow, more so than Europe). I’m waiting on their submission to the FDA to have a read.


  • Registered Users Posts: 11,516 ✭✭✭✭ titan18


    Probably Pfizer, Moderns, J&J and then AZ as the ones I'd least like by a mile.


  • Registered Users Posts: 6,960 ✭✭✭ ceadaoin.


    Danno wrote: »
    In a hypothetical world where there is an abundance of supply of every brand, all of which are approved, and your vaccine appointment is now due. You are asked which vaccine would you like to take or even not take any? And why?

    This isn't a hypothetical world here in the US. I can walk into a pharmacy tomorrow and get vaccinated if I so choose, with Pfizer, Moderna or J&J. Only J&J for me though just because its only 1 shot and a more traditional type of vaccine, so I would book a place that is offering that one. I will only do it if it makes travelling easier, given my age and risk profile for covid.


  • Registered Users Posts: 5,494 ✭✭✭ Russman


    ceadaoin. wrote: »
    This isn't a hypothetical world here in the US. I can walk into a pharmacy tomorrow and get vaccinated if I so choose, with Pfizer, Moderna or J&J. Only J&J for me though just because its only 1 shot and a more traditional type of vaccine, so I would book a place that is offering that one. I will only do it if it makes travelling easier, given my age and risk profile for covid.

    Out of curiosity, do you need any documentation to do this, or can anyone walk in and get a jab ? If a tourist were to find themselves in the States could they rock up and get vaccinated in a pharmacy ?


  • Registered Users Posts: 2,039 ✭✭✭ theguzman


    I will be getting vaccinated privately outside of Ireland next week, I have a choice of Pfizer/BioNtech, AstraZeneca, Sputnik V and BBIBP-CorV the Chinese Sinopharm COVID-19 vaccine. Right now I am undecided between Sputnik V and Pfizer/BioNtech, I won't take AZ or the Chinese one. I'm hoping for Pfizer but honestly I have great faith in Sputnik V also. I'm in my mid thirties with no underlying condition and I think the HSE has made a dogs dinner of the rollout at home and the Govt could not have made a worse job of everything if they tried.


  • Registered Users Posts: 6,960 ✭✭✭ ceadaoin.


    Russman wrote: »
    Out of curiosity, do you need any documentation to do this, or can anyone walk in and get a jab ? If a tourist were to find themselves in the States could they rock up and get vaccinated in a pharmacy ?

    You need ID, and when it was restricted to certain groups, like casino workers or those with underlying conditions, you had to show proof that you were in that category. Now it's open to anyone over 16. I'd imagine though that they wouldn't really care if you showed them a foreign passport, I mean you could be an immigrant who hasn't got their drivers license sorted yet.


  • Moderators, Social & Fun Moderators, Society & Culture Moderators, Regional North Mods, Regional West Moderators Posts: 81,470 Mod ✭✭✭✭ biko


    I would probably go with Sputnik if it was available.


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  • Registered Users Posts: 1,164 ✭✭✭ Flying Fox


    Pfizer, Moderna or J&J. Basically any approved vaccine other than AZ.


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