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What exactly is happening with AstraZeneca?

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Comments

  • #2


    https://www.google.ie/amp/s/amp.cnn.com/cnn/2021/07/02/health/germany-covid-vaccines-mixing-intl/index.html

    Looks like if u had the first shot of AstraZeneca, Germany recommending u take Pfizer or Moderna if u can’t take 2nd jab.


  • #2


    For anyone who doesn’t want to take the second AZ dose , My friend got a mixed dose of AZ first then Pfizer after getting a letter from her consultant.


  • #2


    For anyone who doesn’t want to take the second AZ dose , My friend got a mixed dose of AZ first then Pfizer after getting a letter from her consultant.

    I think you should set up a new thread for yourself to post on called the following:

    I hate astrazeneca vaccine please only post negative things on this thread. Anything bordering remotely positive on said vaccine is definitely not welcome


  • #2


    Woody79 wrote: »
    I think you should set up a new thread for yourself to post on called the following:

    I hate astrazeneca vaccine please only post negative things on this thread. Anything bordering remotely positive on said vaccine is definitely not welcome

    That’s not very constructive.
    I’ve merely posted to update people that mixed vaccines are being administered in Ireland if patients insist and with your doctors approval. As I said I feel there are better vaccines out there and I’m not the only one who believes so. Plenty of people refused AZ first and second doses because they felt they were being sold short. Just because you don’t like that doesn’t mean it isn’t a fact. You could perhaps acknowledge the differences in vaccines instead of being the bleeding heart poster boy for AZ in Ireland. What’s your fixation with it out if interested?
    Attack the post, not the poster.


  • #2


    That’s not very constructive.
    I’ve merely posted to update people that mixed vaccines are being administered in Ireland if patients insist and with your doctors approval. As I said I feel there are better vaccines out there and I’m not the only one who believes so. Plenty of people refused AZ first and second doses because they felt they were being sold short. Just because you don’t like that doesn’t mean it isn’t a fact. You could perhaps acknowledge the differences in vaccines instead of being the bleeding heart poster boy for AZ in Ireland. What’s your fixation with it out if interested?
    Attack the post, not the poster.

    I have seen your posts on this thread, all them are very negative towards this vaccine?

    Can you show me a post or can you bring yourself to say something positive about this vaccine?

    I have posted positive and negative about this vaccine and other vaccines.

    There is positives and negatives with all the vaccines.

    Thats what a thread is about.

    Your fixation is only how can I say something negative about AZ today.

    You mentioned last week that Sarah Gilbert should feel shame for people that died of blood clots after taking AZ.

    A relative of a person how died of a blood clot in UK came out and said take the vaccine.

    25 million people in UK have taken this vaccine and you come on here as if they have taken poison.

    99.99% of the population dont feel like that about this vaccine.

    Your views on this vaccine are not balanced.

    You pollute this thread.

    In a constructive way I think you should set up a thread were you can be as negative about this vaccine as you like with other like minded posters.

    Alot of posters on this thread have taken AZ (700K in ireland) and your basically saying to them they are idiots or have been duped.

    I think you should be apologising for that post about Sarah Gilbert. Most reasonable people would think its actually disgusting.


  • #2


    Wolf359f wrote:
    I haven't seen a breakdown of the 2nd dose rate by the EMA, would you have a link, I'm curious what breakdowns they have for age/sex etc...

    Check the EMA EU Pharmacovigilance website. All EU reported side effect reporting data is there.

    I ran some data crunching and compared e.g. reported cases of anaphylactic shock or thrombocytopenia for both Pfizer-BioNtech and Oxford AstraZeneca.

    Pfizer - 300M doses administered
    AZ - 75M doses

    Anaphylaxis - 2x likely for AZ in this dataset
    Thrombocytopenia - 10x likely in this dataset

    I didn't look into the CSVT though...


  • #2


    topdecko wrote:
    I have fielded calls from multiple people who have had extreme reactions to first dose AZ and under no circumstances will they take second dose of AZ. whilst the incidence of CVST and other clotting disorders is of the order of 1/200,000 i would suspect significant reactions and exaggerated immune response are many times higher. Other european countries are mixing and matching vaccines and we will here at some point. The volte face on the AZ vaccine has to be explained to the youth and that it is not ideal but a pragmatic response to emergence of this new variant. Very conflicting advice coming from NIAC at times.

    Yes this is supported by EU Pharmacovigilance data. AZ an order of magnitude harsher than Pfizer in terms of side effects.


  • #2


    For anyone who doesn’t want to take the second AZ dose , My friend got a mixed dose of AZ first then Pfizer after getting a letter from her consultant.

    Your friend got a consultant to medically recommend a different vaccine for a non medical reason?

    What's the name of this consultant? Lay out your cards here.


  • #2


    McGiver wrote: »
    I don't trust current HMG figures, especially in relation to this very much politicised vaccine. It's been used by the Johnsonist regime as a propaganda tool to show "benefits of Brexit" (of course a lie and nonsense).

    EMA estimates the CVST incidence at 1 in 200,000.
    McGiver wrote: »
    Check the EMA EU Pharmacovigilance website. All EU reported side effect reporting data is there.

    I ran some data crunching and compared e.g. reported cases of anaphylactic shock or thrombocytopenia for both Pfizer-BioNtech and Oxford AstraZeneca.

    Pfizer - 300M doses administered
    AZ - 75M doses

    Anaphylaxis - 2x likely for AZ in this dataset
    Thrombocytopenia - 10x likely in this dataset

    I didn't look into the CSVT though...
    OP was concerned about CVST risk for their second dose, I supplied evidence that the risk is lower on the second dose. You don't trust the UK data and quote the EMA risk. So where is the EMA stating the risk of CVST on a second dose at 1 in 200,000?


  • #2


    astrofool wrote: »
    Your friend got a consultant to medically recommend a different vaccine for a non medical reason?

    What's the name of this consultant? Lay out your cards here.

    The medical reason is my friend is very high risk under the age of 30 on immunosuppressants and is entitled to a mRNA vaccine to offer higher protection.

    You can PM me if you need further information on the consultant, although I suspect you want it for nefarious reasons.

    Friend was told at the MVC that a few people have got mixed regimen.


  • #2


    The medical reason is my friend is very high risk under the age of 30 on immunosuppressants and is entitled to a mRNA vaccine to offer higher protection.

    You can PM me if you need further information on the consultant, although I suspect you want it for nefarious reasons.

    Friend was told at the MVC that a few people have got mixed regimen.

    That medical reason doesn't make sense, there is virtually no difference between AZ and mRNA for protection and AZ may end up having the longer lasting protection, it also doesn't make sense for immuno suppressed as mRNA is more dependent on the immune system working well to be effective (due to the spike protein production step). There's some important details being left out here.

    I can see a mixed regime being recommended when there has been a reaction to the first vaccine dose, but this can be equally mRNA to AZ as AZ to mRNA.


  • #2


    astrofool wrote: »
    That medical reason doesn't make sense, there is virtually no difference between AZ and mRNA for protection and AZ may end up having the longer lasting protection, it also doesn't make sense for immuno suppressed as mRNA is more dependent on the immune system working well to be effective (due to the spike protein production step). There's some important details being left out here.

    I can see a mixed regime being recommended when there has been a reaction to the first vaccine dose, but this can be equally mRNA to AZ as AZ to mRNA.

    Explain what you mean about Astra being better than an mrna for the immune depressed
    Are there some new papers on this
    My doctor and specialist told me The opposite and insisted on Pfizer
    You have me worried now


  • #2


    Explain what you mean about Astra being better than an mrna for the immune depressed
    Are there some new papers on this
    My doctor and specialist told me The opposite and insisted on Pfizer
    You have me worried now

    They're just doing clinical trials at the moment:
    https://clinicaltrials.gov/ct2/show/NCT04805216?term=BNT162b2&cond=immunocompromised&draw=2&rank=5

    There's no data saying one type of vaccine is better than the other for immuno suppressed (hence surprising why a consultant would put their medical opinion behind this).

    Given the mechanisms at play (and this is my opinion only), the adenovector vaccines would likely be able to provoke an immune response easier (here's a virus with a spike, react to it) vs. mRNA (here's instructions to make a spike which you will then react to), in the real world, there is likely negligible difference between the two., but it will be interesting to see what the studies show.

    There is also a good chance that the protein based Novavax ends up being the vaccine of choice for immunosuppressed, but again, that's pure speculation on my part (this is just based on historically what has worked).


  • #2


    astrofool wrote: »
    Given the mechanisms at play (and this is my opinion only), the adenovector vaccines would likely be able to provoke an immune response easier (here's a virus with a spike, react to it) vs. mRNA (here's instructions to make a spike which you will then react to), in the real world, there is likely negligible difference between the two., but it will be interesting to see what the studies show.

    The adenovector vaccines are similar to the mRNA ones in that they both delivery mRNA payloads in order for your own ribosomes to produce the actual proteins. Main difference is Pfizer/Moderna use lipid nanoparticles to carry the mRNA whereas AZ/J&J include the mRNA in a viral carrier.


  • #2


    astrofool wrote: »
    They're just doing clinical trials at the moment:
    https://clinicaltrials.gov/ct2/show/NCT04805216?term=BNT162b2&cond=immunocompromised&draw=2&rank=5

    There's no data saying one type of vaccine is better than the other for immuno suppressed (hence surprising why a consultant would put their medical opinion behind this).

    Given the mechanisms at play (and this is my opinion only), the adenovector vaccines would likely be able to provoke an immune response easier (here's a virus with a spike, react to it) vs. mRNA (here's instructions to make a spike which you will then react to), in the real world, there is likely negligible difference between the two., but it will be interesting to see what the studies show.

    There is also a good chance that the protein based Novavax ends up being the vaccine of choice for immunosuppressed, but again, that's pure speculation on my part (this is just based on historically what has worked).

    Thats fine but please don't be giving your non medical opinion here
    I'm not saying that to offend you
    Its just that it's dangerous because it might worry people
    People are best not asking about friends conditions here either,it's for their doctors and frankly I trust mine


  • #2


    Thats fine but please don't be giving your non medical opinion here
    I'm not saying that to offend you
    Its just that it's dangerous because it might worry people
    People are best not asking about friends conditions here either,it's for their doctors and frankly I trust mine

    Noted, I was trying to get details from a poster who has, frankly, been hysterically anti-AZ in the face of data to the contrary. If you are immuno-compromised, do pay attention to that study, results are expected around November.

    Edit: I would also note that all content in the forum is an opinion unless backed by a study, sometimes an educated opinion, sometimes not, go and look at the conspiracy forum for the amount of running away posters do when asked to provide some evidence for their theories.


  • #2


    Myself and my wife both had side effects from first dose of AZ. We have now both received the 2nd dose with absolutely no side effects at all, not even a sore arm. Night and Day difference.


  • #2


    The Moderna vaccine has been offered here now,... anyone know if this is a pfizer or an AZ type?


  • #2


    loughside wrote: »
    The Moderna vaccine has been offered here now,... anyone know if this is a pfizer or an AZ type?

    mRNA, like Pfizer.


  • #2


    astrofool wrote: »
    Noted, I was trying to get details from a poster who has, frankly, been hysterically anti-AZ in the face of data to the contrary. If you are immuno-compromised, do pay attention to that study, results are expected around November.

    Edit: I would also note that all content in the forum is an opinion unless backed by a study, sometimes an educated opinion, sometimes not, go and look at the conspiracy forum for the amount of running away posters do when asked to provide some evidence for their theories.


    What you posted above was complete bull****.

    I would advise anyone concerned about the post not to pay it the slightest heed.


  • #2


    What you posted above was complete bull****.

    I would advise anyone concerned about the post not to pay it the slightest heed.

    Luckily we have your brains to rely on:
    So those who are vaccinated with AZ are twice (8%) as likely to end up in hospital that those who received Pfizer (4%).
    This is not true.

    Two doses of the AstraZeneca vaccine were 60% effective against symptomatic disease from the delta variant.
    Why does the UK seem to be the only western country badly affected by the Delta variant?

    Is it an inherent weakness in the AstraZeneca vaccine?

    This is not objective or data led posting.


  • #2


    secman wrote: »
    Myself and my wife both had side effects from first dose of AZ. We have now both received the 2nd dose with absolutely no side effects at all, not even a sore arm. Night and Day difference.

    That was my experience too, and it seems to be commonplace for AZ.


  • #2


    Your posts give dangerous misinformation, astrofool.
    astrofool wrote: »
    Luckily we have your brains to rely on:







    This is not objective or data led posting.


    Wow. This is more than a bit obsessive, astrofool.


  • #2


    What you posted above was complete bull****.

    I would advise anyone concerned about the post not to pay it the slightest heed.
    Your posts give dangerous misinformation, astrofool.




    Wow. This is more than a bit obsessive, astrofool.

    Incapable of interacting in a civil manner

    Do not post in this thread again


  • #2

    Cruise lines in US refusing recognise AZ as it’s not approved by FDA

    Countries such as Malta refusing entry to those batches of AZ made in India as not approved by EMA

    Barbados refusing entry to those with 1 AZ 1 some other vaccine combinations

    that's just from a couple of hours searching for holidays and reading entry requirements



  • #2


    What is happening with the dose interval with AZ for younger people?

    I know some are registering now and being told AZ is on offer and they may receive it sooner than if they choose to wait for another vaccine. The HSE vaccine website says "You should get your second dose 4 to 12 weeks after your first dose.", but that doesn't really seem like any kind of guarantee when it will be received. I just know some younger people who are considering taking the AZ vaccine with the hope that they might be fully vaccinated sooner than waiting for another vaccine, but if they end up on a 12 week interval that might not be the case at all.

    If anyone knows some more detail or experience that would be great to share



  • #2


    The policy as I understood it has been changed to 4 weeks interval between doses

    Still having 12 weeks as even a possibility on the HSE site seems out of kilter to me



  • #2


    I think that's still there for the second doses currently being administered (and will hopefully be finished by next week). The new interval is 4 weeks (give or take a few days).



  • #2


    I got AZ as a first dose the 12th May and my second dose the 9th July , eight weeks and a few days between doses. At the time they were predicting up to 16 weeks between doses. Its the same now hey are saying 4-16 weeks. I say you could lay the house that most people opting for AZ will get second dose in 4-6 weeks. However as dealing with COVID is a fluid situation the HSE are covering eventualities in case they may need to give mRNA as second shots. I would not be surprised if those hat got AZ as first shot in younger age cohort got mRNA as booster shot.

    We have been here before with people predicting that we fail in January with the nslowness of he process at the start, we had it with AZ failing to deliver that we would not get enough vaccination. There was predictions hat U30's would get no vaccination before Oct/Nov.

    people should stop trying to double think he process. AZ can be boosted up beyond 16 weeks HSE is just keeping its option open unless other data comes to light that may need them to change there plans. If AZ is available it up to people to make there own decision. I would not be worrying about upper limits but look at lower limits.


    I got my digital Covid cert during the week



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