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A reaction that you would predict fingolimod would undergo...

  • 03-04-2011 5:22pm
    #1
    Tevez101
    Closed Accounts Posts: 111 ✭✭


    ........giving the product and the
    mechanism.


    If you could give me a head start on this it would be great.

    Cheers.


Comments

  • #2
    SOL
    Registered Users, Registered Users 2 Posts: 1,155 ✭✭✭SOL


    Do you mean what reactions can you do to 2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol or what things might happen to it if you eat it?

    I mean if you are looking for a list of reactions that you do to this then that is going to be quite long... you have a 1,3 diol, an amine and an aromatic ring as well as two benzylic positions that you could probably do reactions on,

    As for metabolism well, I don't konw so much here, but I'd imagine you could either get oxidation or phosphorilation of the alcohols... I'm sure lots of other things might happen, maybe someone else will know more...


  • #3
    AaronEnnis
    Registered Users, Registered Users 2 Posts: 151 ✭✭AaronEnnis


    Fingolimod acts on the S1p receptor, as its an MS drug... so the active form would be fingolimod phosphate. Im guessing the drug is converted to the phosphate form by kinase/ATP. Also, the drug is ingested orally so phase ii metabolism would be responsible for some glucuronidation, probably for renal excretion. That lovely long non-polar chain won't be much good for excretion!


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