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Vaccines - correlates and surrogates

  • 04-08-2008 2:39pm
    #1
    r3nu4l
    Registered Users, Registered Users 2 Posts: 17,399 ✭✭✭✭


    Some of you fine people may know the answer to this better than I do.

    I've been asked about vaccine correlates and surrogates and have been doing some reading. So far I've found that surrogates for vaccine immungenicity might include antibody (end point titre or isotype) responses.

    While increases in IL-4 and IL-5 may well be a correlate to increases in antibody titres, their measurement (levels of IL-4, IL-5) is not a surrogate for measuring immunogenicity. Is this a correct assumption?

    My thinking is that just because you see a rise in cytokines that induce the humoral immune response does not mean that you will see a huge humoral response, perhaps due to other confounders such as even higher levels of cytokines promoting a cell mediated response.

    Comments and further clarification welcome...it's been a while since I actively worked on vaccines and adjuvants in the lab.


Comments

  • #2
    tallaght01
    Closed Accounts Posts: 5,778 ✭✭✭tallaght01


    r3nu4l wrote: »
    Some of you fine people may know the answer to this better than I do.

    I've been asked about vaccine correlates and surrogates and have been doing some reading. So far I've found that surrogates for vaccine immungenicity might include antibody (end point titre or isotype) responses.

    While increases in IL-4 and IL-5 may well be a correlate to increases in antibody titres, their measurement (levels of IL-4, IL-5) is not a surrogate for measuring immunogenicity. Is this a correct assumption?

    My thinking is that just because you see a rise in cytokines that induce the humoral immune response does not mean that you will see a huge humoral response, perhaps due to other confounders such as even higher levels of cytokines promoting a cell mediated response.

    Comments and further clarification welcome...it's been a while since I actively worked on vaccines and adjuvants in the lab.

    Just saw this.

    It's all about the antibody titres, to my mind. It's all we measure routinely when trying to work out of someone has been fully immunised.


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