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neurobiology

  • 23-11-2005 6:41pm
    #1
    ronbyrne2005
    Closed Accounts Posts: 3,494 ✭✭✭


    anyone knwo anything about the effects of ssri's on receptor levels in brains long term damage if any etc or how long it takes brain to return to its normal receptor /neurotransmitter levels and production/function after ssri's


Comments

  • #2
    John
    Registered Users, Registered Users 2 Posts: 12,135 ✭✭✭✭John


    SSRIs don't do anything (known) directly to receptors as they act on the serotonin reuptake transporter protein (SERT). If anything I'd say treatment with SSRIs will gradually increase the numbers of serotonin receptors present as the cells are receiving more serotonin signals which down the line causes the receiving cell to make more synapses. This is a current area of research, antidepressant treatment increases levels of proteins called neurotrophins after about two weeks of treatment (neurotrophins are believed to be the molecules that actually cause the anti-depressive effects).

    As for normal receptor/neurotransmitter levels, the reason for someone going on SSRIs is because they have below average levels (of one or both). SSRIs bring up the levels to normal and depending on the disease being treated, levels should stay at normal. In some diseases the effects return after about two years of SSRI treatment because a tolerance builds up to the drugs.


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