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Gamma GT query

  • 18-06-2009 7:00pm
    #1
    nesf
    Registered Users Posts: 27,645 ✭✭✭✭


    Am just curious about this and I don't think it falls under the category of medical advice despite it being about myself.

    I'm just curious as to the actual mechanism and cause here. My GGT is high (90-113 U/L over the past year) and the reason for this is medication rather than alcohol (I barely manage 1 drink a month over the past year). I'm on 1600mg Trileptal (Oxcarbazepine), 400mg Seroquel (Quetiapine) and 25mg Anafranil (Clomipramine) and 4g of L-typtophan a day at the moment. I'm told it's most likely the Oxcarbazepine that is causing this and I'm curious as to what exactly underlies this change. Is Oxcarbazepine a heptatoxic drug or is there something else going on?


Comments

  • #2
    DrIndy
    Registered Users Posts: 3,461 ✭✭✭DrIndy


    i don't think you're looking for medical advice - you are looking for information why liver enzymes are raised with certain drugs.

    I will need to do a bit of research first though to give a clear response - any pharmacologists out there?


  • #3
    tallaght01
    Closed Accounts Posts: 5,778 ✭✭✭tallaght01


    Is it not just enzyme induction? GGT is an enzyme. but i don't do science anymore :P


  • #4
    charlieroot
    Registered Users Posts: 196 ✭✭charlieroot


    Did a small bit of research on this, more to learn something about the medications and enzyme induction/ liver damage than to try and give you a definitive answer (I'm certainly not qualified to do so), here's what I came up with:


    1600mg Trileptal (Oxcarbazepine)
    Appendix 2 (Liver Disease) BNF “Manufacturer advises caution in severe hepatic impairment – no information given.”

    400mg Seroquel (Quetiapine)
    Nothing about liver damage or enzyme induction in BNF

    25mg Anafranil (Clomipramine)
    BNF side effects : “abnormal liver function tests (jaundice)”

    4g L-typtophan
    Not in the BNF couldn't really find anything relevant on this.


    Other things (besides certain drugs, alcohol and liver disease) which can cause raised GGT:
    Smoking.
    Increases with age in women.
    GGT is about twice as high in persons of African ancestry in comparison to those of European ancestry.

    You might find this interesting as well:
    http://nelh2004.sequence.co.uk/index.cfm?question=1374


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